Adipogen/IBMX/AG-CR1-3512-G001/1 g
商品编号：
AG-CR1-3512-G001
品牌：
Adipogen Inc
市场价：
¥3100.00
美元价：
1860.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | 3-Isobutyl 1-methylxanthine; NSC 165960; EINECS 249-259-3 |
| Product Type | Chemical |
| Properties | |
| Formula | C10H14N4O2 |
| MW | 222.3 |
| CAS | 28822-58-4 |
| RTECS | ZD8500000 |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO, ethanol or methanol. Insoluble in water. |
| InChi Key | APIXJSLKIYYUKG-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Cell permeable, competitive, non-specific cAMP and cGMP phosphodiesterase inhibitor [1, 5, 6, 11].
- Increases cAMP levels that activate PKA, leading to decreased proliferation, increased differentiation and induction of apoptosis [9].
- Enhances differentiation of 3T3-L1 cells [3].
- Non-selective adenosine receptor antagonist [4].
- Inhibits Ca2+ ion channels [7, 8].
- Activates TNF-α [10].
- Adipogenic [10].
- Activates leukotriene synthesis [12].
- Reduces inflammation and innate immunity [12].
Product References
- Effects of xanthine derivatives on lipolysis and on adenosine 3',5'- monophosphate phosphodiesterase activity: J.A. Beavo, et al.; Mol. Pharmacol. 6, 597 (1970)
- Inhibition of growth of primary and metastatic Lewis lung carcinoma cells by the phosphodiesterase inhibitor isobutylmethylxanthine: P. Janik, et al.; Cancer Res. 40, 1950 (1980)
- A role for soluble cAMP phosphodiesterases in differentiation of 3T3-L1adipocytes: M.L. Elks & V.C. Manganiello; J. Cell Physiol. 124, 191 (1985)
- Adenosine receptors: development of selective agonists and antagonists: J.W. Daly, et al.; Prog. Clin. Biol. Res. 230, 41 (1987)
- Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors: J.A. Beavo & D.H. Reifsnyder; TIPS 11, 150 (1990)
- Isobutylmethylxanthine and other classical cyclic nucleotide phosphodiesterase inhibitors affect cAMP-dependent protein kinase activity: C. Tomes, et al.; Cell Signal. 5, 615 (1993)
- IBMX induces calcium release from intracellular stores in rat sensory neurones: Y. Usachev & A. Verkhratsky; Cell Calcium 17, 197 (1995)
- Inhibition of recombinant human cardiac L-type Ca2+ channel α1C subunits by 3-isobutyl-1-methylxanthine: I.M. Fearon, et al.; Eur. J. Pharmacol. 342, 353 (1998)
- Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas: T.C. Chen, et al.; Lab. Invest. 78, 165 (1998)
- The phosphodiesterase inhibitor IBMX suppresses TNF-alpha expression in human adipocyte precursor cells: a possible explanation for its adipogenic effect: F. Hube, et al.; Horm. Metab. Res. 31, 359 (1999)
- Cyclic nucleotide phosphodiesterases: D.M. Essayan; J. Allergy Clin. Immunol. 108, 671 (2001)
- Leukotrienes: underappreciated mediators of innate immune responses: M. Peters-Golden, et al.; J. Immunol. 174, 589 (2005)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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