Adipogen/IBMX/AG-CR1-3512-M500/500 mg
商品编号：
AG-CR1-3512-M500
品牌：
Adipogen Inc
市场价：
¥1900.00
美元价：
1140.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 3-Isobutyl1-methylxanthine;NSC165960;EINECS249-259-3 |
| ProductType | Chemical |
| Properties | |
| Formula | C10H14N4O2 |
| MW | 222.3 |
| CAS | 28822-58-4 |
| RTECS | ZD8500000 |
| PurityChemicals | ≥99%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO,ethanolormethanol.Insolubleinwater. |
| InChiKey | APIXJSLKIYYUKG-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeable,competitive,non-specificcAMPandcGMPphosphodiesteraseinhibitor[1,5,6,11].
- IncreasescAMPlevelsthatactivatePKA,leADIngtodecreasedproliferation,increaseddifferentiationandinductionofapoptosis[9].
- Enhancesdifferentiationof3T3-L1cells[3].
- Non-selectiveadenosinereceptorantagoNIST[4].
- InhibitsCa2+ionchannels[7,8].
- ActivatesTNF-α[10].
- Adipogenic[10].
- Activatesleukotrienesynthesis[12].
- Reducesinflammationandinnateimmunity[12].
ProductReferences
- Effectsofxanthinederivativesonlipolysisandonadenosine3",5"-monophosphatephosphodiesteraseactivity:J.A.Beavo,etal.;Mol.Pharmacol.6,597(1970)
- InhibitionofgrowthofprimaryandmetastaticLewislungcarcinomacellsbythephosphodiesteraseinhibitorisobutylmethylxanthine:P.Janik,etal.;CancerRes.40,1950(1980)
- AroleforsolublecAMPphosphodiesterasesindifferentiationof3T3-L1adipocytes:M.L.Elks&V.C.Manganiello;J.CellPhysiol.124,191(1985)
- Adenosinereceptors:developmentofselectiveagonistsandantagonists:J.W.Daly,etal.;Prog.Clin.Biol.Res.230,41(1987)
- Primarysequenceofcyclicnucleotidephosphodiesteraseisozymesandthedesignofselectiveinhibitors:J.A.Beavo&D.H.Reifsnyder;TIPS11,150(1990)
- IsobutylmethylxanthineandotherclassicalcyclicnucleotidephosphodiesteraseinhibitorsaffectcAMP-dependentproteinkinaseactivity:C.Tomes,etal.;CellSignal.5,615(1993)
- IBMXinducescalciumreleasefromintracellularstoresinratsensoryneurones:Y.Usachev&A.Verkhratsky;CellCalcium17,197(1995)
- InhibitionofrecombinanthumancardiacL-typeCa2+channelα1Csubunitsby3-isobutyl-1-methylxanthine:I.M.Fearon,etal.;Eur.J.Pharmacol.342,353(1998)
- Up-regulationofthecAMP/PKApathwayinhibitsproliferation,inducesdifferentiation,andleadstoapoptosisinmalignantgliomas:T.C.Chen,etal.;Lab.Invest.78,165(1998)
- ThephosphodiesteraseinhibitorIBMXsuppressesTNF-alphaexpressioninhumanadipocyteprecursorcells:apossIBLeexplanationforitsadipogeniceffect:F.Hube,etal.;Horm.Metab.Res.31,359(1999)
- Cyclicnucleotidephosphodiesterases:D.M.Essayan;J.AllergyClin.Immunol.108,671(2001)
- Leukotrienes:underappreciatedmediatorsofinnateimmuneresponses:M.Peters-Golden,etal.;J.Immunol.174,589(2005)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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