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Adipogen/IAXO-103 (CD14/TLR4 Antagonist) (synthetic)/IAX-600-003-M005/5 mg
Adipogen/IAXO-103 (CD14/TLR4 Antagonist) (synthetic)/IAX-600-003-M005/5 mg
商品编号：
IAX-600-003-M005
品牌：
Adipogen Inc
市场价：
¥8500.00
美元价：
5100.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | N-(3,4-bis-Tetradecyloxy-benzyl)-N-cyclopentyl-N,N-dimethylammoniumiodide |
| ProductType | Chemical |
| Properties | |
| Formula | C42H78INO2 |
| MW | 755.98g/mol(iodidesalt) |
| CAS | 1202208-36-3 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥98%(TLC) |
| Appearance | Whitesolid. |
| Solubility | SolubleinMethanol,DMSOandEthanol1:1(vol:vol):>10mM. |
| BIOLOGicalActivity | Describedtointerferewithhuman,ratandmouseTLR4/CD14signaling,otherspeciesnottested.Optimalworkingconcentrationdependsuponthetype,purityandconcentrationandofTLR4ligand,carrierproteinsuchasLPS-bindingprotein(LBP),solubleandmembrane-boundCD14,thepresenceofTLR4co-receptors(e.g.CD36)aswellasontypeandtimeofread-out(e.g.cytokinemeasurementincellculturesupernatant)orthebiologicaloutcomeofinvivoexperimentsandthereforeneedstobedeterminedforeachapplication.Recommendedstartingconcentration:invitro:5μM,invivo(rodent):3mg/kg.Controlcompound:IAXO-202(Cat.No.:IAX-600-005). |
| Identity | DeterminedbyNMRandMS. |
| Declaration | ManufacturedbyInnaxon. |
| OtherProductData | Reconstitution:Fora2mMstocksolution,dissolvetotalvialcontentin661μl(1mgsize)or3,306μl(5mgsize)DMSO/Ethanol(1:1)(vol:vol). |
| InChiKey | InChI=1/C42H78NO2.HI/c1-5-7-9-11-13-15-17-19-21-23-25-29-35-44-41-34-33-39(38-43(3,4)40-31-27-28-32-40)37-42(41)45-36-30-26-24-22-20-18-16-14-12-10-8-6-2;/h33-34,37,40H,5-32,35-36,38H2,1-4H3;1H/q+1;/p-1/fC42H78NO2.I/h;1h/qm;-1 |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- CD14/TLR4antagoNIST.Inhibitorofsterileinflammation.
- SyntheticTLR4/CD14ligandwithTLR4modulatingactivitiesinvitro,andconferringprotectionagainstTLR4/CD14-mediatedtissuedamageandinflammationinvivo.UsefultoexploreCD14-dependentandTLR4-independentpathwaysandTLR4activationbyendogenousligands(e.g.hyaluronicacidoligosaccharides,oxLDL,HMGB1)insterileinflammation.Showntoinhibitneuropathicpain,secondarynecrosisofacutedrug-inducedliverfailureandvascularinflammation,andaBDominalaorticaneurysmbyblockingnon-hematopoieticTLR4signaling.Usefultool,whereinhibitionofsterile(auto-)inflammationisdesired,withoutcompromisingTLR4’skeyroleinthedefenseofpathogens.
ProductReferences
- Inhibitionoflipidastimulatedactivationofhumandendriticcellsandmacrophagesbyaminoandhydroxylaminomonosaccharides:F.Peri,etal.;Angew.Chem.46,3308(2007)
- TLR4receptorasnewtargettotreatneuropathicpain:efficacyofanewreceptorantagonistinamodelofperipheralnerveinjuryinmice:I.Bettoni,etal.;Glia56,1312(2008)
- Glycolipidsandbenzylammoniumlipidsasnovelantisepsisagents:synthesisandbiologicalcharacterization:M.Piazza,etal.;J.Med.Chem.52,1209(2009)
- EvidenceofaspecificinteractionbetweennewsyntheticantisepsisagentsandCD14:M.Piazza,etal.;Biochemistry48,12337(2009)
- ExploringtheLPS/TLR4signalpathwaywithsmallmolecules:F.Peri,etal.;Biochem.Soc.Trans.38,1390(2010)(Review)
- TherapeutictargetingofinnateimmunitywithToll-likereceptor4(TLR4)antagonists:F.Peri&M.Piazza;Biotechnol.Adv.30,251(2012)(Review)
- SyntheticmoleculesandfunctionalizednanoparticlestargetingtheLPS-TLR4signaling:Anewgenerationofimmunotherapeutics:F.Peri,etal.;PureAppl.Chem.84,97(2012)(Review)
- Tolllikereceptor4antagonistpreventsacetaminopheninducedacuteliverfailureinmice:anoveltherapeuticstrategy:N.Shah,etal.;Gut61,A28(2012)
- Multivalentglycoconjugatesasanti-pathogenicagents.A.Bernardi,etal.;Chem.Soc.Rev.42,4709(2013)(Review)
- Toll-likereceptor4(TLR4)modulationbysyntheticandnaturalcompounds:anupdate:F.Peri&V.Calabrese;Med.Chem.57,3612(2014)(Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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