Adipogen/Hypothemycin/BVT-0067-C250/250 µg
商品编号：
BVT-0067-C250
品牌：
Adipogen Inc
市场价：
¥2200.00
美元价：
1320.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| ProductType | Chemical |
| Properties | |
| Formula | C19H22O8 |
| MW | 378.4 |
| CAS | 76958-67-3 |
| Source/HostChemicals | IsolatedfromPhomasp. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSOoracetone;insolubleinmethanolorwater. |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBioViotica. |
| InChiKey | SSNQAUBBJYCSMY-KNTMUCJRSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Afterreconstitutionprotectfromlightat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antifungal.
- Cytotoxicagainstsometumorcelllines,partlyattributedtoinhibitionofRas-inducIBLegenes.
- InhibitsproliferationofmouseandhumanTcells.
- ModulatesproductionofcytokinesduringTcellactivation.
- FacilitatestheubiquitinylationprocessofcyclinD1.
- Potentandselectivethreonine/tyrosine-specifickinase,MEKandotherproteinkinasesinhibitorinbothinvitroandinvivostudies.
ProductReferences
- MetabolitesofpyrenomycetesXIII:Structureof(+)hypothemycin,anantibioticmacrolidefromhypomycestrichothecoides:M.S.R.Nair&S.T.Carey;TetrahedronLett.21,2011(1980)
- Metabolitesofpyrenomycetes.XIV:Structureandpartialstereochemistryoftheantibioticmacrolideshypothemycinanddihydrohypothemycin:M.S.R.Nair,etal.;Tetrahedron37,2445(1981)
- Revisedstructureandstereochemistryofhypothemycin:T.Agatsumaetal.;Chem.Pharm.Bull.41,373(1993)
- Antitumorefficacyofhypothemycin,anewRas-signalinginhibitor:H.Tanaka,etal.;Jpn.J.CancerRes.90,1139(1999)
- HypothemycininhibitstheproliferativeresponseandmodulatestheproductionofcytokinesduringTcellactivation:R.Camacho,etal.;Immunopharmacology44,255(1999)
- Resorcylicacidlactones:naturallyoccurringpotentandselectiveinhibitorsofMEK:A.Zhao,etal.;J.Antibiot.52,1086(1999)
- SuppressionofoncogenictransformationbyhypothemycinassociatedwithacceleratedcyclinD1degradationthroughubiquitin-proteasomepathway:H.Sonoda,etal.;LifeSci.65,381(1999)
- Targetedcovalentinactivationofproteinkinasesbyresorcylicacidlactonepolyketides:A.Schirmer,etal.;PNAS103,4234(2006)
- ChemistryandBIOLOGyofresorcylicacidlactones:N.Winssinger,etal.;Chem.Commun.(Camb).1,22(2007),(Review)
- TheresorcyclicacidlactoneHypothemycinselectivelyinhibitsthemitogen-activatedproteinkinasekinase-extracellularsignal-regulatedkinasepathwayincells:H.Fukazawa,etal.;Biol.Pharm.Bull.33,168(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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