Adipogen/Hypericin/AG-CN2-0449-M010/10 mg
商品编号：
AG-CN2-0449-M010
品牌：
Adipogen Inc
市场价：
¥5000.00
美元价：
3000.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Mycoporphyrin;NSC407313;Hypericumred |
| ProductType | Chemical |
| Properties | |
| Formula | C30H16O8 |
| MW | 504.5 |
| MerckIndex | 14:4863 |
| CAS | 548-04-9 |
| Source/HostChemicals | IsolatedfromHypericumperforatum. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Darkbrowntoblack-redsolid. |
| Solubility | Solublein100%ethanol,methanolorDMSO.Inpurewater,hypericinformsaggregateswhicharenon-solubleandnon-fluorescent. |
| InChiKey | BTXNYTINYBABQR-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Keepcoolanddry. Keepunderinertgas. Protectfromlight. Protectfrommoistureandoxygen. Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- OneoftheprincipalactiveconstituentsofSt.John"sWort(Hypericumperforatum).
- Hypericinisaphotosensitivepigment/chromophorewithbrightredfluorescenceemission(&lamBDa;max:594nm).
- HasahightripletquantumyieldandabilitytoproduceconsiderableamountsofsingletoxygenandotherROSspecieswhenphotoactivated.
- Antiviral,anticancerandantidepressantagent.
- Inactivatesenvelopedviruses(includingHIV).
- Thisphotosensitizingagenthasshowntoinduceapoptosisandnecrosisincancercellsduringphotodynamictherapy.
- SelectiveinhibitorofproteinkinaseC(PKC).HasbeenshowntoinhibitotherkinasesandtargetssuchasEGFR-PTK,PI3K,CKII,MAPKandinsulinreceptor(IR).
- Necrosis-avidcontrastagentinvestigatedforuseinnon-invasivelytargetingnecrotictissues,basedontobedefinedcomponentsinthephospholipidbilayer.
ProductReferences
- Ontheabsorptionspectrumofhypericin:N.Pace&G.Mackinney;JACS61,3594(1939)
- Hypericinanditsphotodynamicaction:N.Duran&P.S.Song;Photochem.Photobiol.43,677(1986)(Review)
- HypericinandpseudohypericinspecificallyinhibitproteinkinaseC:possIBLerelationtotheirantiretroviralactivity:I.Takahashi,etal.;BBRC165,1207(1989)
- VirucidalActivityofHypericinAgainstEnvelopedandNon-envelopedDNAandRNAViruses:J.Tang,etal.;Antivir.Res.13,313(1990)
- Agentsfortreatinghumanimmunodeficiencyvirusinfection:E.P.Acosta&C.V.Fletcher;Am.J.Hosp.Pharm.51,2251(1994)(Review)
- Photosensitizedinhibitionofgrowthfactor-regulatedproteinkinasesbyhypericin:P.Agostinis,etal.;Biochem.Pharmacol.49,1615(1995)
- ThechemicalandBIOLOGicalpropertiesofhypericin-acompoundwithabroadspectrumofbiologicalactivities:G.Lavie,etal.;Med.Res.Rev.15,111(1995)(Review)
- Naturalproductsderivedfromplantsaspotentialdrugsforthephotodynamicdestructionoftumorcells:R.Ebermann,etal.;J.Photochem.Photobiol.B.36,95(1996)(Review)
- Apoptoticandanti-apoptoticsignalingpathwaysinducedbyphotodynamictherapywithhypericin:P.Agostinis,etal.;Adv.EnzymeRegul.40,157(2000)(Review)
- StJohn"swort(HypericumperforatumL.):areviewofitschemistry,pharmacologyandclinicalproperties:J.Barnes,etal.;J.Pharm.Pharmacol.53,583(2001)(Review)
- Hypericinincancertreatment:morelightontheway:P.Agostinis,etal.;Int.J.Biochem.CellBiol.34,221(2002)(Review)
- Hypericin-anewantiviralandantitumorphotosensitizer:mechanismofactionandinteractionwithbiologicalmacromolecules:P.Miskovsky;Curr.DrugTargets3,55(2002)(Review)
- MechanismofactionofStJohn"swortindepression:whatisknown?V.Butterweck;CNSDrugs17,539(2003)(Review)
- Celldeathandgrowtharrestinresponsetophotodynamictherapywithmembrane-boundphotosensitizers:J.Piette,etal.;Biochem.Pharmacol.66,1651(2003)(Review)
- Hypericin-thefactsaboutacontroversialagent:A.Kubin,etal.;Curr.Pharm.Des.11,233(2005)
- Themultifacetedphotocytotoxicprofileofhypericin:T.A.Theodossiou,etal.;Mol.Pharm.6,1775(2009)(Review)
- Molecularresponsetohypericin-inducedphotodamage:B.Krammer&T.Verwanger;Curr.Med.Chem.19,793(2012)(Review)
- NecrosisAvidity:anewlydiscoveredfeatureofhypericinanditspreclinicalapplicationsinnecrosisimaging:B.Jiang,etal.;Theranostics3,667(2013)(Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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