Adipogen/Hypericin/AG-CN2-0449-M001/1 mg
商品编号：
AG-CN2-0449-M001
品牌：
Adipogen Inc
市场价：
¥1000.00
美元价：
600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Mycoporphyrin; NSC407313; Hypericum red |
| Product Type | Chemical |
| Properties | |
| Formula | C30H16O8 |
| MW | 504.5 |
| Merck Index | 14: 4863 |
| CAS | 548-04-9 |
| Source/Host Chemicals | Isolated from Hypericum perforatum. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Dark brown to black-red solid. |
| Solubility | Soluble in 100% ethanol, methanol or DMSO. In pure water, hypericin forms aggregates which are non-soluble and non-fluorescent. |
| InChi Key | BTXNYTINYBABQR-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice |
Keep cool and dry. Keep under inert gas. Protect from light. Protect from moisture and oxygen. Protect from light when in solution. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- One of the principal active constituents of St. John's Wort (Hypericum perforatum).
- Hypericin is a photosensitive pigment/chromophore with bright red fluorescence emission (λmax: 594nm).
- Has a high triplet quantum yield and ability to produce considerable amounts of singlet oxygen and other ROS species when photoactivated.
- Antiviral, anticancer and antidepressant agent.
- Inactivates enveloped viruses (including HIV).
- This photosensitizing agent has shown to induce apoptosis and necrosis in cancer cells during photodynamic therapy.
- Selective inhibitor of protein kinase C (PKC). Has been shown to inhibit other kinases and targets such as EGFR-PTK, PI3K, CKII, MAPK and insulin receptor (IR).
- Necrosis-avid contrast agent investigated for use in non-invasively targeting necrotic tissues, based on to be defined components in the phospholipid bilayer.
Product References
- On the absorption spectrum of hypericin: N. Pace & G. Mackinney; JACS 61, 3594 (1939)
- Hypericin and its photodynamic action: N. Duran & P.S. Song; Photochem. Photobiol. 43, 677 (1986) (Review)
- Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity: I. Takahashi, et al.; BBRC 165, 1207 (1989)
- Virucidal Activity of Hypericin Against Enveloped and Non-enveloped DNA and RNA Viruses: J. Tang, et al.; Antivir. Res. 13, 313 (1990)
- Agents for treating human immunodeficiency virus infection: E.P. Acosta & C.V. Fletcher; Am. J. Hosp. Pharm. 51, 2251 (1994) (Review)
- Photosensitized inhibition of growth factor-regulated protein kinases by hypericin: P. Agostinis, et al.; Biochem. Pharmacol. 49, 1615 (1995)
- The chemical and biological properties of hypericin - a compound with a broad spectrum of biological activities: G. Lavie, et al.; Med. Res. Rev. 15, 111 (1995) (Review)
- Natural products derived from plants as potential drugs for the photodynamic destruction of tumor cells: R. Ebermann, et al.; J. Photochem. Photobiol. B. 36, 95 (1996) (Review)
- Apoptotic and anti-apoptotic signaling pathways induced by photodynamic therapy with hypericin: P. Agostinis, et al.; Adv. Enzyme Regul. 40, 157 (2000) (Review)
- St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties: J. Barnes, et al.; J. Pharm. Pharmacol. 53, 583 (2001) (Review)
- Hypericin in cancer treatment: more light on the way: P. Agostinis, et al.; Int. J. Biochem. Cell Biol. 34, 221 (2002) (Review)
- Hypericin - a new antiviral and antitumor photosensitizer: mechanism of action and interaction with biological macromolecules: P. Miskovsky; Curr. Drug Targets 3, 55 (2002) (Review)
- Mechanism of action of St John's wort in depression: what is known? V. Butterweck; CNS Drugs 17, 539 (2003) (Review)
- Cell death and growth arrest in response to photodynamic therapy with membrane-bound photosensitizers: J. Piette, et al.; Biochem. Pharmacol. 66, 1651 (2003) (Review)
- Hypericin - the facts about a controversial agent: A. Kubin, et al.; Curr. Pharm. Des. 11, 233 (2005)
- The multifaceted photocytotoxic profile of hypericin: T.A. Theodossiou, et al.; Mol. Pharm. 6, 1775 (2009) (Review)
- Molecular response to hypericin-induced photodamage: B. Krammer & T. Verwanger; Curr. Med. Chem. 19, 793 (2012) (Review)
- Necrosis avidity: a newly discovered feature of hypericin and its preclinical applications in necrosis imaging: B. Jiang, et al.; Theranostics 3, 667 (2013) (Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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