Adipogen/Hyperforin . DCHA/AG-CN2-0008-C500/500 µg
商品编号：
AG-CN2-0008-C500
品牌：
Adipogen Inc
市场价：
¥2300.00
美元价：
1380.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (1R,5R,6R,7S)-2-Hydroxy-6-methyl-1,3,7-tris(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)-5-(2-methylpropanoyl)bicyclo[3.3.1]non-2-ene-4,9-dione.DCHA |
| ProductType | Chemical |
| Properties | |
| Formula | C35H51O4.C12H24N |
| MW | 535.8.182.3 |
| CAS | 238074-03-8 |
| Source/HostChemicals | IsolatedfromSt.John"swort(Hypericumperforatum). |
| PurityChemicals | ≥97%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | Solublein100%ethanol,methanolorDMSO. |
| OtherProductData | TheDCHAsaltstABIlizeshyperforinwhichnormallyhasonlyashortshelflife. |
| InChiKey | ZUYCAROZOLUHJY-DNSWOBEMSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepunderinertgas. Protectfromlight. |
| Use/Stability | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- KeyconstituentofSt.John"swort.
- Showspropertiesofpotentialpharmacologicalinterest,includingantibacterial[1],anti-malarial[13],anti-inflammatory[7,14],anti-cancerandanti-angiogeniceffects[5,10].
- Anti-depressantandanxiolyticcompound[3].
- SpecificactivatorofTRPC6channels[11].
- Inhibitsthere-uptakeofneurotransmittersinsynapses(SEROtonin,norepinephrine,dopamine,GABA,glutamate)[4].
- ActivatorofthepregnaneXreceptor(PXR)[2].
- RegulatesexpressionofthecytochromeP450CYP3A4andCYP2C9andhepaticdrugsmetabolism[8].
- Potentialanti-Alzheimercompound[6,9,15].
- PotentSIRT1(sirtuin1)andSIRT2(sirtuin2)inhibitor[12].
ProductReferences
- AntibacterialactivityofhyperforinfromStJohn"swort,againstmultiresistantStaphylococcusaureusandgram-positivebacteria:C.M.Schempp,etal.;Lancet353,2129(1999)
- St.John"swortinduceshepaticdrugmetabolismthroughactivationofthepregnaneXreceptor:L.B.Moore,etal.;PNAS97,7500(2000)
- Hyperforin-antidepressantactivitybyanovelmechanismofaction:W.E.Müller,etal.;Pharmacopsychiatry34(Suppl1),S98(2001)
- Hypericumperforatum(StJohn"sWort):anon-selectivereuptakeinhibitor?Areviewoftherecentadvancesinitspharmacology:P.J.Nathan;J.Psychopharmacol.15,47(2001)(Review)
- Inhibitionoftumourcellgrowthbyhyperforin,anovelanticancerdrugfromSt.John"swortthatactsbyinductionofapoptosis:C.M.Schempp,etal.;Oncogene21,1242(2002)
- Dualmodulationofstriatalacetylcholinereleasebyhyperforin,aconstituentofSt.John"swort:M.L.Buchholzer,etal.;J.Pharmacol.Exp.Ther.301,714(2002)
- Hyperforinisadualinhibitorofcyclooxygenase-1and5-lipoxygenase:D.Albert,etal.;Biochem.Pharmacol.64,1767(2002)
- InductionandinhibitionofcytochromesP450bytheSt.John"swortconstituenthyperforininhumanhepatocytecultures:B.J.Komoroski;DrugMetab.Dispos.32,512(2004)
- NMDAreceptor-antagoNISTicpropertiesofhyperforin,aconstituentofSt.John"sWort:V.Kumar,etal.;J.Pharmacol.Sci.102,47(2006)
- Hyperforin,anewleadcompoundagainsttheprogressionofcancerandleukemia?C.Quiney,etal.;Leukemia20,1519(2006)
- Hyperforin-akeyconstituentofSt.John"swortspecificallyactivatesTRPC6channels:K.Leuner,etal.;FASEBJ.21,4101(2007)
- PhloroglucinolderivativesguttiferoneG,aristoforin,andhyperforin:inhibitorsofhumansirtuinsSIRT1andSIRT2:C.Gey,etal.;Angew.Chem.Int.Ed.Engl.46,5219(2007)
- Invitroantimalarialactivityofhyperforin,aprenylatedacylphloroglucinol.Astructure-activitystudy:L.Verotta,etal.;Bioorg.Med.Chem.Lett.17,1544(2007)
- Hyperforinisanoveltypeof5-lipoxygenaseinhibitorwithhighefficacyinvivo:C.Feisst,etal.;Cell.Mol.LifeSci.66,2759(2009)
- NeuroBIOLOGicaleffectsofHyperforinanditspotentialinAlzheimer"sdiseasetherapy:T.N.Griffith,etal.;Curr.Med.Chem.17,391(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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