Adipogen/Herbimycin A/AG-CN2-0429-M001/1 mg
商品编号：
AG-CN2-0429-M001
品牌：
Adipogen Inc
市场价：
¥11800.00
美元价：
7080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AntibioticTAN420F;(15R)-17-Demethoxy-15-methoxy-11-O-methyl-geldanamycin |
| ProductType | Chemical |
| Properties | |
| Formula | C30H42N2O9 |
| MW | 574.7 |
| CAS | 70563-58-5 |
| RTECS | MK3830000 |
| Source/HostChemicals | IsolatedfromStreptomycessp. |
| PurityChemicals | ≥99%(HPLC) |
| Appearance | Yellowsolid. |
| Solubility | Solubleinethanol,methanolDMSOordimethylformamide.Poorlysolubleinwater. |
| InChiKey | MCAHMSDENAOJFZ-JZYYMJJSSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. Afterreconstitutionprotectfromlightat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Benzoquinoneansamycinantibiotic.
- Herbicidalcompound.
- Potent,selective,irreversIBLeandcellpermeableproteintyrosinekinaseinhibitor.
- Inhibitorofv-Src,Yes,Fps,Ros,Bcr-AblandErbBoncogeneproducts.
- Antitumorcompound.
- Antiangiogenic.InhibitsNF-κBactivationandphosphorylationofphospholipaseC-γ1.
- Inhibitorofheatshockprotein90(Hsp90).BindsHsp90anddestabilizesclientproteinsleADIngtotheirubiquitinationandproteasomaldegradation.
- Increasesthesensitivityofcertaincancercellstochemotherapeuticagents.
- Neuroprotective.
- Antiparasitic,antischistosomalagent.
- Antiviral.
- Increasemicrotubulessensitivitytocoldinplants.
ProductReferences
- Herbimycin,anewantibioticproducedbyastrainofStreptomyces:S.Omura,etal.;J.Antibiot.(Tokyo)32,255(1979)
- AnewactivityofherbimycinA:inhibitionofangiogenesis:T.Yamashita,etal.;J.Antibiot.(Tokyo)42,1015(1989)
- EffectsofherbimycinAandvariousSH-reagentsonp60v-srckinaseactivityinvitro:H.Fukazawa,etal;BBRC173,276(1990)
- UseandselectivityofherbimycinAasinhibitorofprotein-tyrosinekinases:Y.Uehara&H.Fukazawa;MethodsEnzymol.201,370(1991)
- SpecificinhibitionofcytoplasmicproteintyrosinekinasesbyherbimycinAinvitro:H.Fukazawa,etal.;Biochem.Pharmacol.42,1661(1991)
- Inductionofdifferentiationofhumanleukemiacellswithastructurallyalteredc-abl(bcr/abl)genebyherbimycinA,aninhibitoroftyrosinekinaseactivity:Y.Honma,etal.;Leukemia6,229(1992)
- EffectofherbimycinA,aninhibitoroftyrosinekinase,onproteintyrosinekinaseactivityandphosphotyrosylproteinsofPh1-positiveleukemiacells:M.Okabe,etal.;Leuk.Res.18,213(1994)
- EvidencefordirectmodificationofNFkappaBbythetyrosinekinaseinhibitor,herbimycinA:T.M.Mahon&L.A.O"Neill;Biochem.Soc.Trans.23,111S(1995)
- HerbimycinAinducesthe20Sproteasome-andubiquitin-dependentdegradationofreceptortyrosinekinases:L.Sepp-Lorenzino,etal.;J.Biol.Chem.270,16580(1995)
- InhibitionofPDGF-inducedphospholipaseDbutnotphospholipaseCactivationbyherbimycinA:B.Y.Kim;BBRC212,1061(1995)
- Specificinductionofthe70-kDheatstressproteinsbythetyrosinekinaseinhibitorherbimycin-Aprotectsratneonatalcardiomyocytes.Anewpharmacologicalroutetostressproteinexpression?S.D.Morris,etal.;J.Clin.Invest.97,706(1996)
- InhibitionofPDGF-inducedphospholipaseCactivationbyherbimycinA:B.Y.Kim,etal.;Biochim.Biophys.Acta1311,33(1996)
- HerbimycinAenhancesapoptoticeffectofchemotherapeuticdrugsonK562cells:H.Ren,etal.;Chin.Med.J.(Engl.)111,678(1998)
- Hsp-90-associatedoncoproteins:multipletargetsofgeldanamycinanditsanalogs:M.V.Blagosklonny;Leukemia16,455(2002)(Review)
- HerbimycinAinducessympatheticneuronsurvivalandprotectsagainsthypoxia:M.C.Cabral-da-Silva,etal.;Neuroreport14,2397(2003)
- NaturalproductoriginsofHsp90inhibitors:Y.Uehara;Curr.CancerDrugTargets3,325(2003)
- HerbimycinAabrogatesnuclearfactor-kappaBactivationbyinteractingpreferentiallywiththeIkappaBkinasebetasubunit:S.Ogino,etal.;Mol.Pharmacol.65,1344(2004)
- c-SrcisrequiredforcomplexformationbetweenthehepatitisCvirus-encodedproteinsNS5AandNS5B:aprerequisiteforreplication:A.Pfannkuche,etal.;Hepatology53,1127(2011)
- Inhibitorsoftyrosinekinasesandphosphatasesasatoolfortheinvestigationofmicrotubuleroleinplantcoldresponse:Y.A.Sheremet,etal.;TsitolGenet.46,3(2012)
- Transcriptomeanalysesofinhibitor-treatedschistosomefemalesprovideevidenceforcooperatingSrc-kinaseandTGFβreceptorpathwayscontrollingmitosisandeggshellformation:C.Buro,etal.;PLoSPathog.9,e1003448(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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