Adipogen/Heptelidic acid/AG-CN2-0118-C250/250 µg
商品编号：
AG-CN2-0118-C250
品牌：
Adipogen Inc
市场价：
¥2200.00
美元价：
1320.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Koningicacid;Avocettin;FO-4443;BRN5091359 |
| ProductType | Chemical |
| Properties | |
| Formula | C15H20O5 |
| MW | 280.3 |
| CAS | 57710-57-3(74310-84-2deleted) |
| Source/HostChemicals | IsolatedfromTrichodermasp. |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO(10mg/ml),ethanol(1mg/ml),methanol(1mg/ml)orwater(1mg/ml). |
| Declaration | ManufacturedbyBiOlinksK.K.withcourtesystrainfromTheKitasatoInstitute. |
| InChiKey | JESMSCGUTIEROV-RTWAVKEYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast3yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic[1,2].
- Potentselectiveglyceraldehyde3-phosphatedehydrogenase(GAPDH)inhibitor.BindstotheessentialCys149residueinthecatalyticsiteofGAPDH[3-7,10,11].
- Anticancercompound[8].Selectivelykillshigh-glycolyticcancercellsthroughglucose-dependentactiveATPdeprivation[12].
- Antimalarial[9].
- Apoptosisinhibitor.DNAfragmentationandcaspase-3activationinhibitor[13,16].
- SelectiveandcompetitiveinhibitorofmammalianDNApolymerasesbeta,lamBDaandterminaldeoxynucleotidyltransferase(TdT)infamilyXofpols[14].
ProductReferences
- Anewsesquiterpeneantibiotic,heptelidicacidproducingorganisms,fermentation,isolationandcharacterization:Y.Itoh,etal.;J.Antibiot.(Tokyo)33,468(1980)
- Structureofheptelidicacid,anewsesquiterpeneantibioticfromfungi:Y.Itoh,etal.;J.Antibiot.(Tokyo)33,525(1980)
- Specificinhibitionofglyceraldehyde-3-phosphatedehydrogenasebykoningicacid(heptelidicacid):A.Endo,etal.;J.Antibiot.(Tokyo)38,920(1985)
- Inactivationofrabbitmuscleglyceraldehyde-3-phosphatedehydrogenasebykoningicacid:K.Sakai,etal.;Biochim.Biophys.Acta952,297(1988)
- Identificationofkoningicacid(heptelidicacid)-modifiedsiteinrabbitmuscleglyceraldehyde-3-phosphatedehydrogenase:K.Sakai,etal.;Biochim.Biophys.Acta1077,192(1991)
- Koningicacid(heptelidicacid)inhibitionofglyceraldehyde-3-phosphatedehydrogenasesfromvarioussources:M.Kato,etal.;Biochim.Biophys.Acta1120,113(1992)
- Glyceraldehyde-3-phosphatedehydrogenaseisrequiredforthetransportofnitricoxideinplatelets:B.McDonald,etal.;PNAS90,11122(1993)
- Antitumoractivityofheptelidicacidchlorohydrin:J.Kawashima,etal.;J.Antibiot.(Tokyo)47,1562(1994)
- AntimalarialactivityofrADIcicol,heptelidicacidandotherfungalmetabolites:Y.Tanaka,etal.;J.Antibiot.(Tokyo)51,153(1998)
- Glyceraldehyde-3-phosphatedehydrogenaseactivityasanindependentmodifierofmethylglyoxallevelsindiabetes:P.J.Beisswenger,etal.;Biochim.Biophys.Acta1637,98(2003)
- D-Glyceraldehydecausesproductionofintracellularperoxideinpancreaticislets,oxidativestress,anddefectivebetacellfunctionvianon-mitochondrialpathways:H.Takahashi,etal.;J.Biol.Chem.279,37316(2004)
- Glucose-dependentactiveATPdepletionbykoningicacidkillshigh-glycolyticcells:S.Kumagai,etal.;BBRC365,362(2008)
- Heptelidicacid,asesquiterpenelactone,inhibitsEtoposide-inducedapoptosisinhumanleukemiaU937cells:J.H.Kim&C.H.Lee;J.Microbiol.Biotechnol.19,787(2009)
- Novelterpenoids,trichoderonicacidsAandBisolatedfromTrichodermavirens,areselectiveinhibitorsoffamilyXDNApolymerases:Y.Yamaguchi,etal.;Biosci.Biotechnol.Biochem.74,793(2010)
- RapideffectorfunctionofmemoryCD8+Tcellsrequiresanimmediate-earlyglycolyticswitch:P.M.Gubser,etal.;Nat.Immunol.14,1064(2013)
- Theimmune-metabolicbasisofeffectormemoryCD4+Tcellfunctionunderhypoxicconditions:S.Dimeloe,etal.;J.Immunol.196,106(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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