Adipogen/Hellebrin/AG-CN2-0475-M005/5 mg
商品编号：
AG-CN2-0475-M005
品牌：
Adipogen Inc
市场价：
¥4000.00
美元价：
2400.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 3β-(O4-β-D-Glucopyranosyl-α-L-rhamnopyranosyloxy)-5,14-dihydroxy-19-oxo-5β,14-β-bufa-20,22-dienolide;NSC93134 |
| ProductType | Chemical |
| Properties | |
| Formula | C36H52O15 |
| MW | 724.8 |
| CAS | 13289-18-4 |
| Source/HostChemicals | IsolatedfromHelleboruspurpurascens. |
| PurityChemicals | ≥99%(HPLCandUVAbsorbance) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | Solubleinwater(~4mg/ml). |
| InChiKey | DCSLTSSPIJWEJN-YRFFWODSSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- HighlypotentNa+/K+-ATPaseinhibitor,blockingtheactiveeffluxofNa+andreuptakeofK+.
- WatersolublecardiotonicglycosidefromtheclassofbufADIenolides(with2-pyronering).
- Inhibitscancercellgrowthinvitro.Showntoinducecaspase-dependentapoptosis,reducingMDRresistanceandtherateofmitochondrialoxidativephosphorylationincancercells.
- InotropicbyincreasingtheintracellularCa2+concentration.
- Immunosuppressiveandanti-inflammatoryagentthatinhibitsallogeneicTcellactivationwithmuchhigherpotencythancortisolorcyclosporinA.
ProductReferences
- UeberHellebrin,einkrystallisiertesGlykosidausRadixHelleborinigri:W.Karrer;Helv.Chim.Acta26,1353(1943)
- Thestructureofhellebrin:P.Muhr,etal.;LiebigsAnn.Org.Bioorg.Chem.2,443(1995)
- Insearchofidealinotropicsteroids:recentprogress:K.R.Repke,etal.;Prog.DrugRes.47,9(1996)
- ExquisitelysmallamountsofnonglucocorticoidnaturalsteroidssuppressthehumanallogeneicT-cellresponse:P.Terness,etal.;TransplantProc.33,547(2001)
- TheT-cellsuppressiveeffectofbufadienolides:structuralrequirementsfortheirimmunoregulatoryactivity:P.Terness,etal.;Int.Immunopharmacol.1,119(2001)
- Apoptosis-mediatedselectivekillingofmalignantcellsbycardiacsteroids:maintenanceofcytotoxicityandlossofcardiacactivityofchemicallymodifiedderivatives:D.Daniel,etal.;Int.Immunopharmacol.3,1791(2003)
- Anti-cancernaturalproductlibraryfromtraditionalchinesemedicine:V.B.Konkimalla&T.Efferth;Comb.Chem.HighThroughputScreen.11,7(2008)
- FTIRspectralsignatureoftheeffectofcardiotonicsteroidswithantitumoralpropertiesonaprostatecancercellline:R.Gasper,etal.;Biochim.Biophys.Acta1802,1087(2010)
- HellebrinanditsaglyconeformhellebrigenindisplaysimilarinvitrogrowthinhibitoryeffectsincancercellsandbindingprofilestothealphasubunitsoftheNa+/K+-ATPase:L.MorenoY.Banuls,etal.;Mol.Cancer12,33(2013)
- Structure-activityrelationshipanalysisofbufadienolide-inducedinvitrogrowthinhibitoryeffectsonmouseandhumancancercells:L.MorenoY.Banuls,etal.;J.Nat.Prod.76,1078(2013)
- NaturalcompoundswithimportantmedicalpotentialfoundinHelleborussp.:M.C.Maior&C.Dobrota;Cent.Eur.J.Biol.8,272(2013)(Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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