Adipogen/Helenalin/AG-CN2-0435-C500/500 µg
商品编号：
AG-CN2-0435-C500
品牌：
Adipogen Inc
市场价：
¥4800.00
美元价：
2880.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | HelenalinA;NSC85236 |
| ProductType | Chemical |
| Properties | |
| Formula | C15H18O4 |
| MW | 262.3 |
| CAS | 6754-13-8 |
| Source/HostChemicals | IsolatedfromArnicachamissonis. |
| PurityChemicals | ≥97%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinethanolorDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | ZVLOPMNVFLSSAA-XEPQRQSNSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Anticancercompound.
- NF-κBinhibitor.
- Apoptosisinducer.
- Potentanti-inflammatoryagent.
- Telomeraseinhibitor.
- Anti-trypanosomalandantiprotozoalcompound
- Antibiotic.
- Showsanti-proliferativeeffectsin3T3-L1preADIpocytes.
- Autophagyinducer.
ProductReferences
- ConstituentsofHeleniumspecies.XIII.ThestructureofHelenalinandMexicaninA:W.Herz,etal.;JACS85,19(1963)
- Antitumoragents.21.Aproposedmechanismforinhibitionofcancergrowthbytenulinandhelenalinandrelatedcyclopentenones:I.H.Hall,etal.;J.Med.Chem.20,333(1977)
- InhibitionofnucleicacidsynthesisinP-388lymphocyticleukemiatumorcellsbyhelenalinandbis(helenalinyl)malonateinvivo:W.L.WilliamsJr,etal.;J.Pharm.Sci.77,178(1988)
- Helenalin,ananti-inflammatorysesquiterpenelactonefromArnica,selectivelyinhibitstranscriptionfactorNF-kappaB:G.Lyss,etal.;J.Biol.Chem.378,951(1997)
- Theanti-inflammatorysesquiterpenelactonehelenalininhibitsthetranscriptionfactorNF-kappaBbydirectlytargetingp65:G.Lyss,etal;J.Biol.Chem.273,33508(1998)
- HelenalintriggersaCD95deathreceptor-independentapoptosisthatisnotaffectedbyoverexpressionofBcl-x(L)orBcl-2:V.M.Dirsch,etal.;CancerRes.61,5817(2001)
- Anti-trypanosomalactivityofhelenalinandsomestructurallyrelatedsesquiterpenelactones:T.J.Schmidt,etal.;PlantaMed.68,750(2002)
- InductionofhumanleukemiaHL-60celldifferentiationviaaPKC/ERKpathwaybyhelenalin,apseudoguainolidesesquiterpenelactone:S.H.Kim,etal.;Eur.J.Pharmacol.511,89(2005)
- Potentinhibitionofhumantelomerasebyhelenalin:P.R.Huang,etal.;CancerLett.227,169(2005)
- NoveleffectofhelenalinonAktsignalingandSkp2expressionin3T3-L1preadipocytes:C.A.Auld,etal.;BBRC346,314(2006)
- HelenalinreducesStaphylococcusaureusinfectioninvitroandinvivo:D.Boulanger,etal.;Vet.Microbiol.119,330(2007)
- Helenalin-mediatedpost-transcriptionalregulationofp21(Cip1)inhibits3T3-L1preadipocyteproliferation:K.M.Fernandes,etal.;J.CellBiochem.105,913(2008)
- HelenalinsuppressesessentialimmunefunctionsofactivatedCD4+Tcellsbymultiplemechanisms:C.Berges,etal.;Mol.Immunol.46,2892(2009)
- HelenalinbypassesBcl-2-mediatedcelldeathresistancebyinhibitingNF-κBandpromotingreactiveoxygenspeciesgeneration:R.Hoffmann,etal.;Biochem.Pharmacol.82,453(2011)
- NF-κBp65repressionbythesesquiterpenelactone,Helenalin,contributestotheinductionofautophagycelldeath:C.B.Lim,etal.;BMCComplement.Altern.Med.12,93(2012)
- NaturalsesquiterpenelactonesinduceprogrammedcelldeathinTrypanosomacruzi:anewtherapeutictarget?:V.Jimenez,etal.;Phytomedicine21,1411(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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