Adipogen/Harmine/AG-CN2-0510-M250/250 mg
商品编号：
AG-CN2-0510-M250
品牌：
Adipogen Inc
市场价：
¥3000.00
美元价：
1800.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole;BaNISTerine;Leucoharmine;Telepathine;Yageine;BRN0178813 |
| ProductType | Chemical |
| Properties | |
| Formula | C13H12N2O |
| MW | 212.3 |
| CAS | 442-51-3 |
| RTECS | UV0175000 |
| Source/HostChemicals | Synthetic.OriginallyisolatedfromtheseedsofPeganumharmala(Syrianrue). |
| PurityChemicals | ≥98% |
| Appearance | Whiteotoff-whitesolid. |
| Solubility | SolubleinDMSO.Slightlysolubleinethanol.Insolubleinwater. |
| OtherProductData | StockSolution:PriortoperformingBIOLOGicalexperimentsthestocksolutionshouldbefurtherdilutedintowaterorotheraqueousbufferstoensurethattheresidualamountofDMSO/ethanolisinsignificant,sinceDMSOandethanolmayhavephysiologicaleffectsathighconcentrations. Wedonotrecommendtostorethestocksolutionformorethanoneday. |
| InChiKey | BXNJHAXVSOCGBA-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. Protectfrommoistureandoxygen. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Fluorescentβ-carbolinealkaloid.
- PotentATP-competitiveandselectiveinhibitorofDYRK1A,DYRK2andDYRK3withIC50valuesof0.08,0.9and0.8µM.ShowntoinhibitCLK2,PIM3(at4.3µM)andCK1at1.5µMaswell.InhibitsDYRK1A-mediatedtauphosphorylation.
- CompetitiveandreversIBLemonoamineoxidaseinhibitor(MAOI)thatreversiblyinhibitsMAO-A(monoamineoxidaseA)buthasnoeffectonMAO-B.
- Acetylcholinesteraseinhibitor(AChEI).Couldpotentiallyameliorateimpairedmemory.
- UsefulfluorescentpHindicator.ShowsacolorchangefrompH7.2(bluefluorescence)topH8.9(yellowfluorescence).WiththerADIoisotopecarbon-11,usedinpositronemissiontomographyneuroimagingtoexamineitsbindingtoMAO-A.
- Antiviralandantileishmanialcompound.
- Antiangiogenicandantitumoragent.Inhibitscellularproliferation,migration,invasionandinducedapoptosisinvitro,aswellasinhibitedtumorgrowthinvivo.
- Antidiabetic.UniqueregulatorofPPARγexpressionthatactsbyinhibitingtheWntsignalingpathwayinacell-specificmanner.Inducespancreaticβ-cellproliferation.Reducedbloodglucose,freefattyacidsandtriglyceridelevels,delayedhyperglycemiaandimprovedinsulinsensitivity.
- ShowntoinduceadipocyteThermogenesisthroughtheRAC1-MEK-ERK-CHD4axis.CHD4directlybindstheproximalpromoterregionofUCP1,servingasanegativemodulatorofUCP1andinducingbrowninginbrown(BAT)andwhiteadiposetissue(WAT).
- InhibitsDNAtopoisomerasesandinterfereswithDNAsynthesis.InteractswithDNAviabothgroovebindingandintercalativemodesandcausemajorDNAstructuralchanges.
- Showntopromotedifferentiationofosteoblasts(bone-formingcells)andchondrocytes(cellsinthecartilage)andtoinhibitosteoclastogenesis(theformationofboneresorbingcells).
- AntimalarialbyinhibitingthePlasmodiumfalciparumheatshockprotein90(PfHSP90)ATP-bindingdomain.
ProductReferences
- ThepH-dependenceoftheabsorptionandfluorescencespectraofharmineandharmol:drasticdifferencesinthetautomericequilibriaofgroundandfirstexcitedsingletstate:O.S.Wolfbeis&E.Furlinger;Z.Physik.Chem.129,171(1982)
- Antiviraleffectofharmine,aphotoactivebeta-carbolinealkaloid:J.B.Hudson,etal.;Photochem.Photobiol.43,21(1986)
- Harmineasasubstitutefor33258HoechstintheFPGtechnique:M.G.Gutierrez-Gonzalvez,etal.;Histochemistry89,199(1988)
- EffectofmoclobemideonratbrainmonoamineoxidaseAandB:comparisonwithharmalineandclorgyline:J.Gerardy;Prog.Neuropsychopharmacol.Biol.Psychiatry18,793(1994)
- 11C-harmineasatracerformonoamineoxidaseA(MAO-A):invitroandinvivostudies:M.Bergstrom,etal.;Nucl.Med.Biol.24,287(1997)
- Antitumoragents201.Cytotoxicityofharmineandbeta-carbolineanalogs:J.Ishida,etal.;Bioorg.Med.Chem.Lett.9,3319(1999)
- Harmine:evaluationofitsantileishmanialpropertiesinvariousvesiculardeliverysystems:S.Lala,etal.;J.DrugTarget12,165(2004)
- Thesmallmoleculeharmineisanantidiabeticcell-type-specificregulatorofPPARgammaexpression:H.Waki,etal.;CellMetab.5,357(2007)
- Theselectivityofproteinkinaseinhibitors:afurtherupdate:J.Bain,etal.;Biochem.J.408,297(2007)
- DYRK1Aphosphorylatescaspase9ataninhibitorysiteandispotentlyinhibitedinhumancellsbyharmine:A.Seifert,etal.;FEBSJ.275,6268(2008)
- HarminespecificallyinhibitsproteinkinaseDYRK1Aandinterfereswithneuriteformation:N.Gockler,etal.;FEBSJ.276,6324(2009)
- β-CarbolinealkaloidsbindDNA:S.Nafisi,etal.;J.Photochem.Photobiol.B:Biol.100,84(2010)
- Harmine,aβ-carbolinealkaloid,inhibitsosteoclastdifferentiationandboneresorptioninvitroandinvivo:T.Yonezawa,etal.;Eur.J.Pharmacol.650,511(2011)
- HarmineisanATP-competitiveinhibitorfordual-specificitytyrosinephosphorylation-regulatedkinase1A(Dyrk1A):T.Adayev,etal.;Arch.Biochem.Biophys.507,212(2011)
- ThesmallmoleculeharmineregulatesNFATc1andId2expressioninosteoclastProgenitorcells:H.Egusa,etal.;Bone49,264(2011)
- β-carbolinecompounds,includingharmine,inhibitDYRK1AandtauphosphorylationatmultipleAlzheimer"sdisease-relatedsites:D.Frost,etal.;PLoSOne6,e19264(2011)
- HarmineisapotentantimalarialtargetingHsp90andsynergizeswithchloroquineandartemisinin:D.Shahinas,etal.;Antimicrob.AgentsChemother.56,4207(2012)
- Harmineinducesapoptosisandinhibitstumorcellproliferation,migrationandinvasionthroughdown-regulationofcyclooxygenase-2expressioningastriccancer:H.Zhang,etal.;Phytomedicine21,348(2014)
- Ahigh-throughputchemicalscreenrevealsthatharmine-mediatedinhibitionofDYRK1Aincreaseshumanpancreaticbetacellreplication:P.Wang,etal.;Nat.Med.21,383(2015)
- Effectsofharmine,anacetylcholinesteraseinhibitor,onspatiallearningandmemoryofAPP/PS1transgenicmiceandscopolamine-inducedmemoryimpairmentmice:D.He,etal.;Eur.J.Pharmacol.768,96(2015)
- Selectivityprofilingandbiologicalactivityofnovelβ-carbolinesaspotentandselectiveDYRK1kinaseinhibitors:K.Ruben,etal.;PLosOne10,e0132453(2015)
- Harmineinducescellcyclearrestandmitochondrialpathway-mediatedcellularapoptosisinSW620cellsviainhibitionoftheAktandERKsignalingpathways:J.Liu,etal.;Oncol.Rep.35,3363(2016)
- HarmineInducesAdipocyteThermogenesisthroughRAC1-MEK-ERK-CHD4Axis:T.Nie,etal.;Sci.Rep.6,36382(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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