Adipogen/H-89 . dihydrochloride/AG-CR1-0002-M001/1 mg
商品编号：
AG-CR1-0002-M001
品牌：
Adipogen Inc
市场价：
¥500.00
美元价：
300.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide.2HCl |
| ProductType | Chemical |
| Properties | |
| Formula | C20H20BrN3O2S.2HCl |
| MW | 446.4.72.9 |
| CAS | 130964-39-5|127243-85-0(freebase) |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSOormethanol. |
| OtherProductData | Stocksolutionsarestableforatleast3-4weekswhenstoredat+4°C.Werecommendusingafreshsolutioneachday. |
| InChiKey | ZKZXNDJNWUTGDK-NSCUHMNNSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- CellpermeablepotentandselectivecAMP-andcGMP-dependentproteinkinase(PKAandPKG)inhibitor[1-3].
- ProteinkinaseCμ(PKCμ)inhibitor[4].
- Ca2+/calmodulin-dependentproteinkinaseIIinhibitor[2].
- CaseinkinaseIinhibitor[2].
- Myosinlightchainkinase(MLCK)inhibitor[2].
- Apoptosisenhancer[5].
- Tooltostudyproteincrystalstructure-inhibitorinteractions[6].
- Rhokinaseinhibitor[7].
- Cellproliferationinhibitor[8].
- Review[9].
ProductReferences
- PolyaminesdifferentiallyinhibitcyclicAMP-dependentproteinkinase-mediatedphosphorylationinthebrainofthetobaccohornworm,Manducasexta.:W.L.Combestetal.;J.NeuRochem.51,1581(1988)
- Inhibitionofforskolin-inducedneuriteoutgrowthandproteinphosphorylationbyanewlysynthesizedselectiveinhibitorofcyclicAMP-dependentproteinkinase,N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide(H-89),ofPC12:T.Chijiwaetal.;J.Biol.Chem.265,5267(1990)
- AselectiveinhibitorofcyclicAMP-dependentproteinkinase,N-[2-bromocinnamyl(amino)ethyl]-5-isoquinolinesulfonamide(H-89),inhibitsphosphatidylcholinebiosynthesisinHeLacells:C.C.Geilenetal.;FEBSLett.309,381(1992)
- CharacterizationofactivatorsandinhibitorsofproteinkinaseCmu:F.J.Johannesetal.;Eur.J.Biochem.227,303(1995)
- ProteinkinaseAinhibitorsenhancerADIation-inducedapoptosis:D.Findiketal.;J.CellBiochem.57,12(1995)
- CrystalstructuresofcatalyticsubunitofcAMP-dependentproteinkinaseincomplexwithisoquinolinesulfonylproteinkinaseinhibitorsH7,H8,andH89.Structuralimplicationsforselectivity:R.A.Enghetal.;J.Biol.Chem.271,26157(1996)
- TheproteinkinaseAinhibitorH89actsoncellmorphologybyinhibitingRhokinase:J.Leemhuis,etal.;J.Pharmacol.Exp.Ther.300,1000(2002)
- H89(N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide)inducesreductionofmyosinregulatorylightchainphosphorylationandinhibitscellproliferation:D.Umeda,etal.;Eur.J.Pharmacol.590,61(2008)
- ThemanyfacesofH89:areview:A.Lochner&J.A.Moolman;Cardiovasc.DrugRev.24,261(2006)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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