Adipogen/H-1152/SYN-1221-M010/10 mg
商品编号：
SYN-1221-M010
品牌：
Adipogen Inc
市场价：
¥6260.00
美元价：
3756.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinolinedihydrochloride;H1152 |
| ProductType | Chemical |
| Properties | |
| Formula | C16H21N3O2S.2HCl |
| MW | 319.4.72.9 |
| CAS | 871543-07-6 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:ROCK|KinaseGroup:AGC|Substrate:Serine-Threonine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | BFOPDSJOLUQULZ-GXKRWWSZSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
H-1152isapotent,specific,ATP-competitiveandcellpermeableROCKinhibitor,withanIC50of12nMforROCKII.H-1152poorlyinhibitsPKA,PKCandmyosinlightchainkinase.Rhokinase(ROCK)activatedbyGTP-linkedRhophosphorylatestargetsthatareinvolvedincytoskeletalremodelling,smoothmusclecontractionandneuronaldevelopment.
ProductReferences
- ThenovelandspecificRho-kinaseinhibitor(S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazineasaprobingmoleculeforRho-kinase-involvedpathway:Y.Sasaki,etal.;Pharmacol.Ther.93,225(2002)
- DevelopmentofspecificRho-kinaseinhibitorsandtheirclinicalapplication:M.Tamura,etal.;Biochim.Biophys.Acta1754,245(2005)
- Proerectileeffectsoftherho-kinaseinhibitor(S)-(+)-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine(H-1152)intheratpenis:C.E.Teixeira,etal.;J.Pharmacol.Exp.Ther.315,155(2005)
- H1152promotesthedegradationofpolyglutamine-expandedataxin-3orataxin-7independentlyofitsROCK-inhibitingeffectandamelioratesmutantataxin-3-inducedneurodegenerationintheSCA3transgenicmouse:H.L.Wang,etal.;Neuropharmacol.70,1(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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