Adipogen/GW806742X/SYN-1215-M001/1 mg
商品编号：
SYN-1215-M001
品牌：
Adipogen Inc
市场价：
¥1940.00
美元价：
1164.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AC1NS7PT;AGN-PC-0LQ49Y |
| ProductType | Chemical |
| Properties | |
| Formula | C25H22F3N7O4S |
| MW | 573.6 |
| CAS | 579515-63-2 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:VEGFR2/YES/MLKL|KinaseGroup:RTK|Substrate:Tyrosine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | SNRUTMWCDZHKKM-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
PotentproteinkinaseVEGFR2inhibitor(2nmrange).BindstothepseudokinasedomainofMLKLandblockscelldeathbynecroptosis,aswell.Withregardstoitsroleinnecroptosis,itisanATP-mimeticthatwasshowntobindrecombinantmouseMLKLpseudokinasedomain,whichshowedinhibitedTSQ-induceddeathofmousedermalfibroblastsbydelayingMLKLtranslocationtothemembrane.Appearsthereforetobeavaluablereagenttoinhibitnecroptosis.Italsoprovidesanimportantproof-of-principlethattargetingcatalytically-deadpseudoenzymesrepresentsafeasIBLe,emergingtherapeuticavenue.
ProductReferences
- DiscoveryofanovelandpotentseriesofdianilinopyrimidineureaandureaisostereinhibitorsofVEGFR2tyrosinekinase:D.M.Sammond,etal.;Bioorg.Med.ChemLett.15,3519(2005)
- ActivationofthepseudokinaseMLKLunleashesthefour-helixbundledomaintoinducemembranelocalizationandnecroptoticcelldeath:J.M.Hildebrand,etal.;PNAS111,15072(2014)
- Identificationandstructure-functionanalysisofsubfamilyselectiveGprotein-coupledreceptorkinaseinhibitors:K.T.Homan,etal.;ACSChem.Biol.10,310(2015)
- NeutrophilnecroptosisistriggeredbyligationofadhesionmoleculesfollowingGM-CSFpriming:X.Wang,etal.;J.Immunol.197,4090(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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