Adipogen/GW501516/AG-CR1-3641-M025/25 mg
商品编号：
AG-CR1-3641-M025
品牌：
Adipogen Inc
市场价：
¥5200.00
美元价：
3120.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | GSK-516;GW1516;Endurobol;2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]aceticacid |
| ProductType | Chemical |
| Properties | |
| Formula | C21H18F3NO3S2 |
| MW | 453.5 |
| CAS | 317318-70-0 |
| RTECS | AI9105500 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO(30mg/ml),dimethylformamide(30mg/ml),ethanol(10mg/ml)ormethanol(30mg/ml).Sparinglysolubleinwater. |
| Identity | Identitydeterminedby1H-NMR/13C-NMR. |
| InChiKey | YDBLKRPLXZNVNB-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentandselectiveperoxisomeproliferator-activatedreceptor(PPAR)δagoNIST/activatorwithhighaffinity(Ki=1nM)andpotency(EC50=1nM)forPPARδand>1000foldselectivityoverPPARαandPPARγ.Theperoxisomeproliferator-activatedreceptorδ(PPARδ)hasemergedasanimportantregulatoroflipidhomeostasisandinflammatorysignaling.Recentinvitro,invivoandhumanclinicalstudieshavehighlightedaroleforPPARδactivationinthepreventionandtreatmentofinsulinresistanceandatherosclerosis.
- Antidiabeticcompound.
- Showntoactivatepathwaysinitiatedthroughexerciseandwasinvestigatedasapotentialtreatmentforobesity,diabetes,dyslipidemiaandcardiovasculardisease.Off-targethighdosesleadtotumorprogressioninrodents.
- IncreasesABCA1transporterexpressionandinducesapolipoproteinA1-mediatedcholesteroleffluxinvitro.
- IncreaseserumHDLcholesterolandlowerssmall-denseLDLlevelsinobesityinvivomodels.
- Reducesplasmatriglycerideconcentration.
- Increasesexpressionofgenesinvolvedinlipidutilization,β-oxidation,cholesteroleffluxandenergyuncoupling,aswellasapolipoprotein-A1specificeffluxofintracellularcholesterol,indicatingthemuscletissueisanimportanttarget.
- Modelcompoundforanewtypeofobesitytherapeutic,aswellasaselectivepharmacologicaltoolforunderstandinglipidmetabolism.
ProductReferences
- Aselectiveperoxisomeproliferator-activatedreceptordeltaagonistpromotesreversecholesteroltransport:W.R.Oliver,etal.;PNAS98,5306(2001)
- Novelselectivesmallmoleculeagonistsforperoxisomeproliferator-activatedreceptordelta(PPARdelta)-synthesisandBIOLOGicalactivity:M.L.Sznaidman,etal.;Bioorg.Med.Chem.Lett.13,1517(2003)
- Theperoxisomeproliferator-activatedreceptorbeta/deltaagonist,GW501516,regulatestheexpressionofgenesinvolvedinlipidcatabolismandenergyuncouplinginskeletalmusclecells:U.Dressel,etal.;Mol.Endocrinol.17,2477(2003)
- Activationofperoxisomeproliferator-activatedreceptordeltainducesfattyacidbeta-oxidationinskeletalmuscleandattenuatesmetabolicsyndrome:T.Tanaka,etal.;PNAS100,15924(2003)
- Peroxisomeproliferator-activatedreceptordeltaandgammaagonistsdifferentiallyaltertumordifferentiationandprogressionduringmammarycarcinogenesis:Y.Yin,etal.;CancerRes.65,3950(2005)
- ActivationofPPARbeta/deltainducesendothelialcellproliferationandangiogenesis:L.Piqueras,etal.;Arterioscler.Thromb.Vasc.Biol.27,63(2007)
- AMPKandPPARdeltaagonistsareexercisemimetics:V.A.Narkar,etal.;Cell134,405(2008)
- Peroxisomeproliferator-activatedreceptordeltaagonistsinhibitThelpertype1(Th1)andTh17responsesinexperimentalallergicencephalomyelitis:S.Kanakasabai,etal.;Immunol.130,572(2010)
- ActivationofPPARδpromotesmitochondrialenergymetabolismanddecreasesbasalinsulinsecretioninpalmitate-treatedβ-cells:L.Jiang,etal.;Mol.CellBiochem.343,249(2010)
- Activationofperoxisomeproliferator-activatedreceptor-{delta}byGW501516preventsfattyacid-inducednuclearfactor-{kappa}Bactivationandinsulinresistanceinskeletalmusclecells:T.Coll,etal.;Endocrinol.151,1560(2010)
- Theroleplayedbytheperoxisomeproliferator-activatedreceptor-β/δ(PPARβ/δ)activator,GW501516,incontroloffattyacidmetabolism:anewpotentialtherapeutictargetfortreatingmetabolicsyndrome:J.Lee&W.Y.Chung;Endocrinol.152,1742(2011)
- Peroxisomeproliferator-activatedreceptorδ:amultifacetedmetabolicplayer:L.A.Bojic&M.W.Huff;Curr.Opin.Lipidol.24,171(2013)(Review)
- HarnessingthebenefitsofPPARβ/δagonists:L.S.Mackenzie&L.Lione;LifeSci.93,963(2013)(Review)
- Short-termadministrationofGW501516improvesinflammatorystateinwhiteADIposetissueandliverdamageinhigh-fructose-fedmicethroughmodulationoftherenin-angiotensinsystem:D.C.Magliano,etal.;Endocrine50,355(2015)
- UnravelingtheEffectsofPPARβ/δonInsulinResistanceandCardiovascularDisease:M.Vazquez-Carrera;TrendsEndocrinol.Metab.27,319(2016)(Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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