Adipogen/GW311616A . hydrochloride/AG-CR1-3632-M025/25 mg
商品编号：
AG-CR1-3632-M025
品牌：
Adipogen Inc
市场价：
¥17800.00
美元价：
10680.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (3S,3aS,6aR)-3-Isopropyl-1-(methylsulfonyl)-4-((E)-4-(piperidin-1-yl)but-2-enoyl)hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one |
| ProductType | Chemical |
| Properties | |
| Formula | C19H31N3O4S.HCl |
| MW | 397.5.36.5 |
| CAS | 197890-44-1 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Solid. |
| Solubility | SolubleinDMSOorwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | UFCZUKYPBPXODT-OFTZGUNKSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potent,selectiveintracellularneutrophilelastase(NE,α-1-proteinase)inhibitor(bycovalentlybindingtoNE).
- Inhibitshumanneutrophilelastase(HNE)andisselectiveoverotherhumanserineproteaseswithIC50valuesof22nMforHNE,>100μMfortrypsin,cathepsinGandplasmin,>3μMforchymotrypsinandtissueplasminogenactivator.
- Specificβ-cellproliferationpromoter.SimilartoSerpinB1,whichfunctionsthroughitsinhibitingactivityofseveralproteasesincludingneutrophilelastase,cathepsinGandproteinase-3.
- ReversesinsulinresistanceandbodyweightgaininHFD-fedmice,suggestingthattheSerpinA1-NEsystemregulatesAMPKsignaling,fattyacidoxidation(FAO)andenergyexpenditure.TheimbalancebetweenSerpinA1(α1-antitrypsin;A1AT)andneutrophilelastaseNEcontributestothedevelopmentofobesityandrelatedinflammation,insulinresistanceandliversteatosis.
- Showntoinhibittumorcellgrowthandproliferationandinduceapoptosisinleukemiacelllines.
ProductReferences
- Thediscoveryofapotent,intracellular,orallybioavailable,longdurationinhibitorofhumanneutrophilelastase-GW311616Aadevelopmentcandidate:S.J.Macdonald,etal.;Bioorg.Med.Chem.Lett.11,895(2001)
- Imbalancebetweenneutrophilelastaseanditsinhibitorα1-antitrypsininobesityaltersinsulinsensitivity,inflammation,andenergyexpenditure:V.Mansuy-Aubert,etal.;CellMetab.17,534(2013)
- Neutrophilelastaseanditstherapeuticeffectonleukemiacells:K.L.Jiang,etal.;Mol.Med.Rep.12,4165(2015)
- SerpinB1PromotesPancreaticβCellProliferation:A.ElOuaamari,etal.;CellMetab.23,194(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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