Adipogen/GSK2126458/SYN-1126-M050/50 mg
商品编号：
SYN-1126-M050
品牌：
Adipogen Inc
市场价：
¥22680.00
美元价：
13608.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | HYR-582 |
| ProductType | Chemical |
| Properties | |
| Formula | C25H17F2N5O3S |
| MW | 505.5 |
| CAS | 1086062-66-9 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO.Slightlysoluble(<1mg l)="" in="" ethanol.=""> |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:PI3K|KinaseGroup:LipidKinase|Substrate:Lipid ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | CGBJSGAELGCMKE-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
GSK2126458isanorallyavailableselectiveinhibitoroftheclassIphosphoinositide3-kinase(PI3K)enzymesandMTOR1/2complexes.GSK2126458caninhibitPI3K-α(p85α/p110α)withIC(50)of0.04nM.GSK2126458hasKivaluesinthepicomolarrangeforeachoftheclassIPI3KisoformsandMTOR1/2complexes.GSK2126458haspotentinvitroandinvivogrowth-inhibitoryeffectsoncancercells.IncomparisonwithotherclinicalPI3Kinhibitors,GSK2126458isaround100-foldmorepotentthanBEZ235(6nM).GSK2126458alsoalowpicomolarinhibitorofthecommonactivatingmutantsofp110R(E542K,E545K,andH1047R)withKiof0.008nM,0.008nMand0.009nMinhumancancer.InmechaNISTiccellularassays,GSK2126458causedasignificantreductioninthelevelsofpAKT-S473withremarkablepotency.ConsistentwithitsactivityagainstbothPI3KRandmTOR,GSK2126458alsoinhibitsphosphorylationofAKT-T308andp70S6Katlownanomolarconcentrations.GSK2126458inducesaG1cellcyclearrestandinhibitscellproliferationinalargepanelofcelllines,includingT47DandBT474breastcancerlines.
ProductReferences
- ThePDBbinddatabase:collectionofbindingaffinitiesforprotein-ligandcomplexeswithknownthree-dimensionalstructures.R.Wang,etal.;J.Med.Chem.47,2977(2004)
- ComparisonoftheeffectsofthePI3K/mTORinhibitorsNVP-BEZ235andGSK2126458ontamoxifen-resistantbreastcancercells:E.Leung,etal.;CancerBiol.Ther.11,938(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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