Adipogen/GNF-5837/SYN-1183-M050/50 mg
商品编号：
SYN-1183-M050
品牌：
Adipogen Inc
市场价：
¥15440.00
美元价：
9264.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | GNF5837 |
| ProductType | Chemical |
| Properties | |
| Formula | C28H21F4N5O2 |
| MW | 535.5 |
| CAS | 1033769-28-6 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:TRK|KinaseGroup:RTK|Substrate:Serine-Threonine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | YYDUWLSETXNJJT-MTJSOVHGSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Inhibitorofpan-Trkactivity(IC(50)=8and12nMforTrkAandTrkB).ShowntotargetTrk(tropomyosinreceptorkinase)ATPbindingcleftandanimmediatelyadjacenthydrophobicpocket.PreferentiallyarreststheproliferationofBa/F3cellsfusedwithTel-TrkA,Tel-TrkBandTel-TrkC(IC(50)=11,9and7nM,respectively)andinBa/F3andRIEcellsexpressingbothTrkAandNGF(IC(50)=42and17nM,respectively)overMo7e-c-KitandRat-A10-PDGFR(IC(50)=1and0.5µM)andBa/F3-Tel-KDRandwt-Ba/F3cells(IC(50)=3.0and5.6µM).Displays~100-foldgreaterselectivityamongapanelof59closelyrelatedkinasesandin33cellularkinaseassays.WeaklyactiveagainstrelevantcytochromeP450isozymesandhERGchannel,andexhibitadequatemicrosomalstability,pharmacokineticprofileandefficacyinmiceandrats.SuppressestumorgrowthinamouseRIE-TrkAmNGFxenograftmodel(50mg/kg,p.o.).
ProductReferences
- DiscoveryofGNF-5837,aSelectiveTRKInhibitorwithEfficacyinRodentCancerTumorModels:P.Albaugh,etal.;ACSMed.Chem.Lett.3,140(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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