Adipogen/GNE-490/SYN-1114-M010/10 mg
商品编号：
SYN-1114-M010
品牌：
Adipogen Inc
市场价：
¥11660.00
美元价：
6996.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | GNE490 |
| ProductType | Chemical |
| Properties | |
| Formula | C18H22N6O2S |
| MW | 386.5 |
| CAS | 1033739-92-2 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:PI3K|KinaseGroup:LipidKinase|Substrate:Lipid ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | SFWTVVNNVHWDEE-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
GNE-490isahighlyselectivepan-PI3KinhibitorthatdemonstratesselectivityovermTOR.Ithasgoodpharmacokinetic(PK)parametersanddemonstratesknockdownofpathwayMarkersinvivo.OriginallyobtainedviamodificationofcompoundslikeGDC-0941,GNE-490whichhaveasignificantlyreducedpotencymTORwhilemaintainingeffectivepotencyforPI3Ksubstrates.IC(50)valuesforPI3Kfamilymembersareinthesubnanomolartolownanomolarrange(-.28to<20nm) while="" ic(50)="" values="" for="" mtor="" and="" other="" related="" tyrosine="" kinases="" are="" greater="" than="" 750nm="" with="" most="" being="" greater="" than="" 1µm="" or="" more,="" thus="" gne-490="" makes="" a="" good="" choice="" for="" examining="" pi3k="" related="" events="" separate="" from="" those="" mediated="" by="">
ProductReferences
- Discoveryof(thienopyrimidin-2-yl)aminopyrimidinesaspotent,selective,andorallyavailablepan-PI3-kinaseanddualpan-PI3-kinase/mTORinhibitorsforthetreatmentofcancer:D.P.Sutherlin,etal.;J.Med.Chem.53,1086(2010)
- Design,synthesisand3D-QSARanalysisofnovel2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidinederivativesaspotentialantitumoragents:W.Zhu,etal.;Eur.J.Med.Chem.57,162(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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