Adipogen/Glyburide (USP)/AG-CR1-3613-G010/10 g
商品编号：
AG-CR1-3613-G010
品牌：
Adipogen Inc
市场价：
¥1600.00
美元价：
960.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Diabeta;Glibenclamide |
| ProductType | Chemical |
| Properties | |
| Formula | C23H28ClN3O5S |
| MW | 494.0 |
| MerckIndex | 14:4478 |
| CAS | 10238-21-8 |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO.Slightlysoluble(<1mg l)="" in="" ethanol="" (gentle="" warming).=""> |
| InChiKey | ZNNLBTZKUZBEKO-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antidiabeticcompound.
- BindstoandactivatestheATP-sensitivepotassiumchannels(KATP)inhibitoryregulatorysubunitsulfonylureareceptor1(SUR1).
- Causescellmembranedepolarizationandopeningofvoltage-dependentcalciumchannel.
- Increasesintracellularcalciumandstimulatesinsulinsecretioninβcells
- NLRP3inflammasomeinhibitor.
- Broad-spectrumATP-bindingcassette(ABC)transporterinhibitor.
- Showntohaveanti-leishmanialactivity.
- PotentialinhibitorofCollagenases.
ProductReferences
- Glyburide:asecond-generationsulfonylureahypoglycemicagent.History,chemistry,metabolism,pharmacokinetics,clinicaluseandadverseeffects:J.M.Feldman;Pharmacotherapy5,43(1985)
- ThereceptorforantidiabeticsulfonylureascontrolstheactivityoftheATP-modulatedK+channelininsulin-secretingcells:H.Schmid-Antomarchi,etal.;J.Biol.Chem.262,15840(1987)
- AntidiabeticsulfonylureascontrolactionpotentialpropertiesinheartcellsviahighaffinityreceptorsthatarelinkedtoATP-dependentK+channels:M.Fosset,etal.;J.Biol.Chem.263,7933(1988)
- SensitivityofarenalK+channel(ROMK2)totheinhibitorysulfonylureacompoundglibenclamideisenhancedbycoexpressionwiththeATP-bindingcassettetransportercysticfibrosistransmembraneregulator:C.M.McNicholas,etal.;PNAS93,8083(1996)
- Thesulphonylureaglibenclamideinhibitsmultidrugresistanceprotein(MRP1)activityinhumanlungcancercells:L.Payen,etal.;Br.J.Pharmacol.132,778(2001)
- Glibenclamide,ablockerofK+(ATP)channels,showsantileishmanialactivityinexperimentalmurinecutaneousleishmaniasis:X.Serrano-Martin,etal.;Antimicrob.AgentsChemother.50,4214(2006)
- CFTRinhibitionbyglibenclamiderequiresapositivechargeincytoplasmicloopthree:P.Melin,etal.;Biochim.Biophys.Acta1768,2438(2007)
- GlyburideinhibitstheCryopyrin/Nalp3inflammasome:M.Lamkanfi,etal.;J.Cell.Biol.187,61(2009)
- Glyburideintreatingmalignantcerebraledema.Blockingsulfonylureaone(SUR1)receptors:T.V.Pallan&I.Ahmed;J.Vasc.Interv.Neurol.7,23(2014)
- InvitroBIOLOGicalevaluationofglyburideaspotentialinhibitorofcollagenases:V.L.Bodiga,etal.;Int.J.Biol.Macromol.70,187(2014)
- NLRP3inflammasomeactivationisessentialforparaquat-inducedacutelunginjury:Z.Liu,etal.;Inflammation38,433(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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