Adipogen/Glyburide/SYN-3026-M050/50 mg
商品编号：
SYN-3026-M050
品牌：
Adipogen Inc
市场价：
¥2160.00
美元价：
1296.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Diabeta;Glibenclamide |
| ProductType | Chemical |
| Properties | |
| Formula | C23H28ClN3O5S |
| MW | 494.0 |
| CAS | 10238-21-8 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO.Slightlysoluble(<1mg l)="" in="" ethanol.=""> |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:SUR1|KinaseGroup:|Substrate:N/A ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | ZNNLBTZKUZBEKO-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Glyburide(Diabeta)isananti-diabeticcompoundinaclassofmedicationsknownassulfonylureas,closelyrelatedtosulfaagent.WorksbybindingtoandactivatingtheATP-sensitivepotassiumchannels(KATP)inhibitoryregulatorysubunitsulfonylureareceptor1(SUR1)inpancreaticbeta-cells.Thisinhibitioncausescellmembranedepolarizationopeningvoltage-dependentcalciumchannel.Thisresultsinanincreaseinintracellularcalciuminthebeta-cellandsubsequentstimulationofinsulinrelease.Recentlyitwasshowntoimprovetheoutcomeinanimalstrokemodelsbypreventingbrainswellingandenhancingneuroprotection.ShowntobeaNLRP3inflammasomeinhibitor.
ProductReferences
- Glyburide:asecond-generationsulfonylureahypoglycemicagent.History,chemistry,metabolism,pharmacokinetics,clinicaluseandadverseeffects:J.M.Feldman;Pharmacotherapy5,43(1985)
- ThereceptorforantidiabeticsulfonylureascontrolstheactivityoftheATP-modulatedK+channelininsulin-secretingcells:H.Schmid-Antomarchi,etal.;J.Biol.Chem.262,15840(1987)
- AntidiabeticsulfonylureascontrolactionpotentialpropertiesinheartcellsviahighaffinityreceptorsthatarelinkedtoATP-dependentK+channels:M.Fosset,etal.;J.Biol.Chem.263,7933(1988)
- GlyburideinhibitstheCryopyrin/Nalp3inflammasome:M.Lamkanfi,etal.;J.Cell.Biol.187,61(2009)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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