Adipogen/Gitoxin/AG-CN2-0485-M005/5 mg
商品编号：
AG-CN2-0485-M005
品牌：
Adipogen Inc
市场价：
¥1900.00
美元价：
1140.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Anhydrogitalin; Bigitalin; Pseudodigitoxin; NSC 95099; BRN0077015 |
| Product Type | Chemical |
| Properties | |
| Formula | C41H64O14 |
| MW | 780.9 |
| CAS | 4562-36-1 |
| RTECS | LZ0525000 |
| Source/Host Chemicals | Isolated from Digitalis purpurea L. |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | White powder. |
| Solubility | Soluble in pyridine or DMSO. Sparingly soluble in 100% ethanol or methanol. Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| InChi Key | LKRDZKPBAOKJBT-CNPIRKNPSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Cardiac glycoside. Natural metabolite of digitoxin. Starting material for the synthesis of gitoxin derivatives with activity as cardiac glycosides.
- Uncompetitive inhibitor of the Na+/K+ ATPase activity.
- Inhibits growth of selected human cancer cells.
Product References
- Studies on digitalis glycosides. VII. Gitoroside, digitalonin, and gitoxin pentaacetate: D. Satoh, et al.; Pharm. Bull. 5, 253 (1957)
- Effects of digoxin and gitoxin on the enzymatic activity and kinetic parameters of Na+/K+-ATPase: D. Krstic, et al.; J. Enzyme Inhib. Med. Chem. 19, 409 (2004)
- Na+/K+-ATPase: Activity and inhibition: M. Colovic, et al.; Russ. J. Phys. Chem. A. 83, 1602 (2009)
- A structural view on the functional importance of the sugar moiety and steroid hydroxyls of cardiotonic steroids in binding to Na,K-ATPase: F. Cornelius, et al.; J. Biol. Chem. 288, 6602 (2013)
- Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase: L. Moreno Y. Banuls, et al.; Mol. Cancer 12, 33 (2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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