Adipogen/Gentamicin sulfate (USP Grade)/AG-CN2-0066-G025/25 g
商品编号：
AG-CN2-0066-G025
品牌：
Adipogen Inc
市场价：
¥7800.00
美元价：
4680.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Apogen;Garamycin;GentiomycinC;Refobacin;NSC-82261 |
| ProductType | Chemical |
| Properties | |
| Formula | C21H43N5O7.H2SO4(unspecified) |
| MW | 575.6 |
| MerckIndex | 14:4392 |
| CAS | 1405-41-0 |
| RTECS | LY2625000 |
| Source/HostChemicals | IsolatedfromMicromonosporasp. |
| PurityChemicals | MixtureofgentamicinC1,C1aandC2. |
| Appearance | Whitetooff-whitepowder. |
| Solubility | Solubleinwater.Almostinsolubleinalcoholorether. |
| BIOLOGicalActivity | Potency(drybasis)≥590μg/mg |
| InChiKey | HNCAOLPMSASREN-UCMBPTNBSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Hygroscopic. Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Aminoglycosideantibiotic.
- Proteinsynthesisinhibitor.CausescodonmisreADIngbybindingtothe30Sribosomalsubunit,blockingthetranslocationofpeptidyl-tRNAfromtheacceptorsitetothedonorsite.
- AntibacterialagainstGram-negativeaerobicbacteria,Gram-positivebacteriaandmycoplasmas.
- Usedasaselectionagent(gentamicin-resistancegene)inmolecularbiologyapplications.Broad-spectrumcellcultureantibioticthatisnontoxictovirusesandmammaliancellsatantibacterialandantimycoplasmalconcentrations.Duetoitsextendedstabilityandslowdevelopmentofbacterialresistance,itisausefulantibioticinlong-termvirusundtissueculturestudies.
- Bactericidaleffectsareexertedbythebindingtotheoutermembrane,causingdisruptionofthemembrane.Thisincreasesthepermeabilityofthecellenvelope,leakageofcellcontents,andleadingtoapoptosisandproteolysis(celldeath).
- Causesalsocelldeathbygenerationoffreeradicals,phospholipidosis,extracellularcalcium-sensingreceptorstimulationandenergeticcatastrophe.
ProductReferences
- Gentamicin:antibacterialactivity,clinicalpharmacologyandclinicalapplications:M.Finland;Med.Times97,161(1969)(Review)
- Aminoglycosideuptakeandmodeofaction--withspecialreferencetostreptomycinandgentamicin.I.AntagoNISTsandmutants:R.E.Hancock;J.Antimicrob.Chemother.8,249(1981)(Review)
- Aminoglycosideuptakeandmodeofaction-withspecialreferencetostreptomycinandgentamicin.II.Effectsofaminoglycosidesoncells:E.Hancock;J.Antimicrob.Chemother.8,429(1981)(Review)
- GentamicininteractionwithPseudomonasaeruginosacellenvelope:N.L.Martin&T.J.Beveridge;Antimicrob.AgentsChemother.29,1079(1986)
- SurfaceactionofgentamicinonPseudomonasaeruginosa:J.Kadurugamuwa,etal.;J.Bacteriol.175,5798(1993)
- LeupeptinandE-64,inhibitorsofcysteineproteinases,preventgentamicin-inducedlysosomalphospholipidosisinculturedratfibroblasts:J.P.Montenez,etal.;Toxicol.Lett.73,201(1994)
- Gentamicinasgenetherapy:F.C.Luft;J.Mol.Med.(Berl)80,543(2002)(Review)
- Anintegrativeoverviewonthemechanismsunderlyingtherenaltubularcytotoxicityofgentamicin:Y.Quiros,etal.;Toxicol.Sci.119,245(2011)(Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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