Adipogen/Genistein/AG-CN2-0427-M250/250 mg
商品编号：
AG-CN2-0427-M250
品牌：
Adipogen Inc
市场价：
¥2400.00
美元价：
1440.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | NSC 36586; Baichanin A; Differenol A; 4',5,7-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| Product Type | Chemical |
| Properties | |
| Formula | C15H10O5 |
| MW | 270.2 |
| Merck Index | 14: 4391 |
| CAS | 446-72-0 |
| RTECS | NR2392000 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥99% |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO; slightly soluble in ethanol. Insoluble in water. |
| InChi Key | TZBJGXHYKVUXJN-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Cell-permeable, reversible, substrate competitive tyrosine kinase inhibitor (including EGFR phosphorylation), implicated in almost all cell growth and proliferation signal cascades [1].
- Inhibitor of mammalian DNA topoisomerase II [2].
- Anticancer agent, inducing cell cycle arrest and apoptosis [3].
- Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis [12].
- Binds estrogen receptor β. Can increase the rate of growth of some ER expressing breast cancers [4, 10].
- Potent α-glucosidase inhibitor [5].
- Anthelmintic [6].
- Anti-diabetic. Activates nuclear receptors, oestrogen receptors and peroxisome proliferator-activated receptors (all PPAR isoforms) and it inhibits various enzyme activities [7, 8, 14].
- Inhibitor of GLUT4-mediated glucose uptake in 3T3-L1 adipocytes [9].
- Stimulator of autophagy vacuolization [12].
- Antioxidant [13].
- TRAIL sensitizer [15].
- Acts as an agonist at the GPR30 receptor [16].
- MALT1 inhibitor [17]
- DNA methyltransferase inhibitor [18].
- Genistein exhibits synergistic antibacterial effects on MRSA [19].
Product References
- Genistein, a specific inhibitor of tyrosine-specific protein kinases: T. Akiyama, et al.; J. Biol. Chem. 262, 5592 (1987)
- Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II: J. Markovits, et al.; Cancer Res. 49, 5111 (1989)
- Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptors and the multi-drug resistance gene: G. Peterson & S. Barnes; BBRC 179, 661 (1991)
- Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta: G.G. Kuiper, et al.; Endocrinology 139, 4252 (1998)
- Genistein, a soy isoflavone, is a potent alpha-glucosidase inhibitor: DS. Lee & SH. Lee; FEBS Lett. 501, 84 (2001)
- Anthelmintic efficacy of Flemingia vestita: genistein-induced effect on the activity of nitric oxide synthase and nitric oxide in the trematode parasite, Fasciolopsis buski: P.K. Kar, et al.; Parasitol. Int. 51, 249 (2002)
- Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells: O. Mezei, et al.; J. Nutr. 133, 1238 (2003)
- Peroxisome proliferator-activated receptor gamma (PPARgamma ) as a molecular target for the soy phytoestrogen genistein: Z.C. Dang, et al.; J. Biol. Chem. 278, 962 (2003)
- Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes: M. Bazuine, et al.; BBRC 326, 511 (2005)
- Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations Y.H. Ju, et al.; Carcinogenesis 27, 1292 (2006)
- Phytochemical genistein in the regulation of vascular function: new insights: H. Si & D. Liu; Curr. Med. Chem. 14, 2581 (2007)
- Diet, autophagy, and cancer: a review: K. Singletary & J. Milner; Cancer Epidemiol. Biomarkers Prev. 17, 1596 (2008) (Review)
- Comparison of flavonoids and isoflavonoids as antioxidants: RM. Han, et al.; J. Agric. Food Chem. 57, 3780 (2009)
- Dose-dependent effects of soy phyto-oestrogen genistein on adipocytes: mechanisms of action: Z.C. Dang; Obes. Rev. 10, 342 (2009) (Review)
- Novel HTS strategy identifies TRAIL-sensitizing compounds acting specifically through the caspase-8 apoptotic axis: D. Finlay, et al.; PLoS One 5, e13375 (2010)
- Genistein regulates the IL-1 beta induced activation of MAPKs in human periodontal ligament cells through G protein-coupled receptor 30: L.J. Luo, et al.; Arch. Biochem. Biophys. 522, 9 (2012)
- MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo: L. Fontan, et al.; Cancer Cell 22, 812 (2012)
- DNA methyltransferase-1 inhibitors as epigenetic therapy for cancer: V. Singh, et al.; Curr. Cancer Drug Targets 13, 379 (2013)
- Flavonoids from Sophora moorcroftiana and their synergistic antibacterial effects on MRSA: SY. Wang, et al.; Phytother. Res. 28, 1071 (2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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