Adipogen/Genistein/AG-CN2-0427-M010/10 mg
商品编号：
AG-CN2-0427-M010
品牌：
Adipogen Inc
市场价：
¥600.00
美元价：
360.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NSC36586;BaichaninA;DifferenolA;4",5,7-Trihydroxyisoflavone;5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| ProductType | Chemical |
| Properties | |
| Formula | C15H10O5 |
| MW | 270.2 |
| MerckIndex | 14:4391 |
| CAS | 446-72-0 |
| RTECS | NR2392000 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥99% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO;slightlysolubleinethanol.Insolubleinwater. |
| InChiKey | TZBJGXHYKVUXJN-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cell-permeable,reversIBLe,substratecompetitivetyrosinekinaseinhibitor(includingEGFRphosphorylation),implicatedinalmostallcellgrowthandproliferationsignalcascades[1].
- InhibitorofmammalianDNAtopoisomeraseII[2].
- Anticanceragent,inducingcellcyclearrestandapoptosis[3].
- Antiangiogenicagent,down-regulatesthetranscriptionofgenesinvolvedincontrollingangiogenesis[12].
- Bindsestrogenreceptorβ.CanincreasetherateofgrowthofsomeERexpressingbreastcancers[4,10].
- Potentα-glucosidaseinhibitor[5].
- Anthelmintic[6].
- Anti-diabetic.Activatesnuclearreceptors,oestrogenreceptorsandperoxisomeproliferator-activatedreceptors(allPPARisoforms)anditinhibitsvariousenzymeactivities[7,8,14].
- InhibitorofGLUT4-mediatedglucoseuptakein3T3-L1ADIpocytes[9].
- Stimulatorofautophagyvacuolization[12].
- Antioxidant[13].
- TRAILsensitizer[15].
- ActsasanagoNISTattheGPR30receptor[16].
- MALT1inhibitor[17]
- DNAmethyltransferaseinhibitor[18].
- GenisteinexhibitssynergisticantibacterialeffectsonMRSA[19].
ProductReferences
- Genistein,aspecificinhibitoroftyrosine-specificproteinkinases:T.Akiyama,etal.;J.Biol.Chem.262,5592(1987)
- InhibitoryeffectsofthetyrosinekinaseinhibitorgenisteinonmammalianDNAtopoisomeraseII:J.Markovits,etal.;CancerRes.49,5111(1989)
- Genisteininhibitionofthegrowthofhumanbreastcancercells:independencefromestrogenreceptorsandthemulti-drugresistancegene:G.Peterson&S.Barnes;BBRC179,661(1991)
- Interactionofestrogenicchemicalsandphytoestrogenswithestrogenreceptorbeta:G.G.Kuiper,etal.;Endocrinology139,4252(1998)
- Genistein,asoyisoflavone,isapotentalpha-glucosidaseinhibitor:DS.Lee&SH.Lee;FEBSLett.501,84(2001)
- AnthelminticefficacyofFlemingiavestita:genistein-inducedeffectontheactivityofnitricoxidesynthaseandnitricoxideinthetrematodeparasite,Fasciolopsisbuski:P.K.Kar,etal.;Parasitol.Int.51,249(2002)
- SoyisoflavonesexertantidiabeticandhypolipidemiceffectsthroughthePPARpathwaysinobeseZuckerratsandmurineRAW264.7cells:O.Mezei,etal.;J.Nutr.133,1238(2003)
- Peroxisomeproliferator-activatedreceptorgamma(PPARgamma)asamoleculartargetforthesoyphytoestrogengenistein:Z.C.Dang,etal.;J.Biol.Chem.278,962(2003)
- GenisteindirectlyinhibitsGLUT4-mediatedglucoseuptakein3T3-L1adipocytes:M.Bazuine,etal.;BBRC326,511(2005)
- Genisteinstimulatesgrowthofhumanbreastcancercellsinanovel,postmenopausalanimalmodel,withlowplasmaestradiolconcentrationsY.H.Ju,etal.;Carcinogenesis27,1292(2006)
- Phytochemicalgenisteinintheregulationofvascularfunction:newinsights:H.Si&D.Liu;Curr.Med.Chem.14,2581(2007)
- Diet,autophagy,andcancer:areview:K.Singletary&J.Milner;CancerEpidemiol.BioMarkersPrev.17,1596(2008)(Review)
- Comparisonofflavonoidsandisoflavonoidsasantioxidants:RM.Han,etal.;J.Agric.FoodChem.57,3780(2009)
- Dose-dependenteffectsofsoyphyto-oestrogengenisteinonadipocytes:mechanismsofaction:Z.C.Dang;Obes.Rev.10,342(2009)(Review)
- NovelHTSstrategyidentifiesTRAIL-sensitizingcompoundsactingspecificallythroughthecaspase-8apoptoticaxis:D.Finlay,etal.;PLoSOne5,e13375(2010)
- GenisteinregulatestheIL-1betainducedactivationofMAPKsinhumanperiodontalligamentcellsthroughGprotein-coupledreceptor30:L.J.Luo,etal.;Arch.Biochem.Biophys.522,9(2012)
- MALT1smallmoleculeinhibitorsspecificallysuppressABC-DLBCLinvitroandinvivo:L.Fontan,etal.;CancerCell22,812(2012)
- DNAmethyltransferase-1inhibitorsasepigenetictherapyforcancer:V.Singh,etal.;Curr.CancerDrugTargets13,379(2013)
- FlavonoidsfromSophoramoorcroftianaandtheirsynergisticantibacterialeffectsonMRSA:SY.Wang,etal.;Phytother.Res.28,1071(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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