Adipogen/Genipin/AG-CN2-0481-M500/500 mg
商品编号：
AG-CN2-0481-M500
品牌：
Adipogen Inc
市场价：
¥7800.00
美元价：
4680.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (+)-Genipin;Methyl(1S,2R,6S)-2-hydroxy-9-(hydroxymethyl)-3-oxABIcyclo[4.3.0]nona-4,8-diene-5-carboxylate |
| ProductType | Chemical |
| Properties | |
| Formula | C11H14O5 |
| MW | 226.2 |
| CAS | 6902-77-8 |
| RTECS | GY5828000 |
| Source/HostChemicals | IsolatedfromGardeniajasminoidesEllisfruits. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO(50mg/ml),ethanol(5mg/ml),methanoloracetone.Slightlysolubleinwater. |
| InChiKey | AZKVWQKMDGGDSV-BCMRRPTOSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/Stability | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeableinhibitorofuncouplingprotein2(UCP2).
- Increasesglucose-stimulatedinsulinsecretion,mitochondrialmembranepotentialandATPlevelsinpancreaticislandcells.
- Anticancer,antimetastaticandanti-angiogenicagent.IncreasesBax/Bcl-2ratioandinducesPARPcleavageandcaspase-3-andcaspase-9-mediatedapoptosisinnon-smallcelllungcancer(NSCLC)cells.Sensitizesmultidrug-resistantcancercellstocytotoxicagentsthroughUCP2inhibition.SuppressesthetumorpromotingfunctionofUCP2inacellularmodelofWarburgeffect.
- Anti-inflammatoryagent.UpregulatesnNOS(neuronalnitricoxidesynthase/NOSI)anddecreasesacuteinflammationthroughinhibitionofLPS-inducedNF-κBactivity.Inhibitstoll-likereceptor(TLR)signalingandtheproductionofpro-inflammatorycytokines,preventingsepsisandincreasingsurvivalinanimalmodelsofinfection.
- ModulatesNLRP3inflammasomeactivationandATP-orH2O2-mediatedIL-1βrelease.InhibitsNLRP3andNLRC4inflammasomeactivationviaautophagysuppression.
- Antiviralcompound.ChemicalpromoterofEpstein-Barrvirus(EBV)lyticcycleactivationandsuppressorofEBVinfection.
- Showntohavewoundhealing,neuroprotective,antidepressant,anti-osteoporoticandantioxidativeactivities.
- Protein,collagen,gelatinandchitosannaturalcross-linkingagent.5,000-10,000timeslesscytotoxicthananyothercrosslinkingagents,withfavorablepropertiesofuseintherangeofpH7.4-8.5andtemperaturesbetween25-45°C.
- Showntobeusefulintheconstructionofnoveldrugdeliverysystems,astherawmaterialforgardeniabluepigmentpreparationandastheintermediateforalkaloidsyntheses.
- Producesbluecoloredpigmentsbybindingtoaminoacids.Simple,safe,sensitiveandstablealternativeforcolorimetricdeterminationofaminoacids.
- Showninforensicresearchtobeanovelfingerprintreagentwithcolorimetricandfluorogenicactivity.
ProductReferences
- Naturallyoccurringoxygenheterocyclics.IX.Isolationandcharacterizationofgenipin:C.Djerassi,etal.;J.Org.Chem.25,2174(1960)
- Preventionoftheneurotoxicityoftheamyloidbetaproteinbygenipin:M.Yamazaki,etal.;Biol.Pharm.Bull.24,1454(2001)
- ColorimetricdeterminationofaminoacidsusinggenipinfromGardeniajasminoides:S.W.Lee,etal.; Anal.Chim.Acta480,267(2003)
- Genipin-anovelfingerprintreagentwithcolorimetricandfluorogenicactivity:J.Almog,etal.;J.ForensicSci.49,255(2004)
- CyclicGMP-dependentneuriteoutgrowthbygenipinandnervegrowthfactorinPC12hcells:M.Yamazaki,etal.;Eur.J.Pharmacol.488,35(2004)
- Antiinflammatoryeffectsofgenipin,anactiveprincipleofgardenia:H.J.Koo,etal.;Eur.J.Pharmacol.495,201(2004)
- GenipininhibitsUCP2-mediatedprotonleakandacutelyreversesobesity-andhighglucose-inducedbetacelldysfunctioninisolatedpancreaticislets:C.Y.Zhang,etal.;CellMetab.3,417(2006)
- Genipinexhibitsneurotrophiceffectsthroughacommonsignalingpathwayinnitricoxidesynthase-expressingcells:M.Yamazaki&K.Chiba;Eur.J.Pharmacol.581,255(2008)
- Neuroprotectiveactionofgenipinontunicamycin-inducedcytotoxicityinneuro2acells:M.Tanaka,etal.;Biol.Pharm.Bull.32,1220(2009)
- Antidepressant-likeeffectofgenipininmice:J.S.Tian,etal.;Neurosci.Lett.479,236(2010)
- Genipininducedapoptosisassociatedwithactivationofthec-JunNH2-terminalkinaseandp53proteininHeLacells:H.Cao,etal.;Biol.Pharm.Bull.33,1343(2010)
- Genipin-inducedinhibitionofuncouplingprotein-2sensitizesdrug-resistantcancercellstocytotoxicagents:R.J.Mailloux,etal.;PLoSOne5,e13289(2010)
- CellularmodelofWarburgeffectidentifiestumorpromotingfunctionofUCP2inbreastcanceranditssuppressionbygenipin:V.Ayyasamy,etal.;PLoSOne6,e24792(2011)
- GenipinattenuatessepsisbyinhibitingToll-likereceptorsignalling:T.H.Kim,etal.;Mol.Med.18,455(2012)
- Up-regulationofTIMP-1bygenipininhibitsMMP-2activitiesandsuppressesthemetastaticpotentialofhumanhepatocellularcarcinoma:N.Wang,etal.;PLoSOne7,e46318(2012)
- Genipin-thenaturalwatersolublecross-linkingagentanditsimportanceinthemodifieddrugdeliverysystems:anoverview:B.Manickam,etal.;Curr.DrugDeliv.11,139(2014)(Review)
- GenipininhibitsRANKL-inducedosteoclastdifferentiationthroughproteasome-mediateddegradationofc-FosproteinandsuppressionofNF-κBactivation:C.H.Lee,etal.;J.Pharmacol.Sci.124,344(2014)
- GenipinasanovelchemicalactivatorofEBVlyticcycle:M.Son,etal.;J.Microbiol.53,155(2015)
- GenipinsuppressesNLRP3inflammasomeactivationthroughuncouplingprotein-2:V.Rajanbabu,etal.;CellImmunol.297,40(2015)
- GenipininhibitsNLRP3andNLRC4inflammasomeactivationviaautophagysuppression:S.X.Yu,etal.;Sci.Rep.5,17935(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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