Adipogen/Geldanamycin/BVT-0196-C500/500 µg
商品编号：
BVT-0196-C500
品牌：
Adipogen Inc
市场价：
¥700.00
美元价：
420.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NSC122750;BRN1633093;U-29135 |
| ProductType | Chemical |
| Properties | |
| Formula | C29H40N2O9 |
| MW | 560.6 |
| CAS | 30562-34-6 |
| RTECS | LX8920000 |
| Source/HostChemicals | IsolatedfromStreptomyceshygroscopicus. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Yellowsolid. |
| Solubility | SolubleinmethanolorDMSO;insolubleinwater. |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBioViotica. |
| InChiKey | QTQAWLPCGQOSGP-GAEFGYQESA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Afterreconstitutionprotectfromlightat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic.
- Potentantitumorcompound.
- pp60srctyrosinekinaseinhibitor.
- Inhibitsc-mycgeneexpressioninmurinelymphoblastomacells.
- Inhibitsthetransformingactivityofabl,erbB,fps,srcandyes.
- Bindsspecificallytoheatshockprotein90(HSP90)andtoitsendoplasmicreticulumhomologGP96(GRP94).
- Destabilizesseveraloncogeneandproto-oncogeneproducts.
- Potentnuclearhormonereceptorfamilyinhibitor.
ProductReferences
- Geldanamycin,anewantibiotic:C.DeBoer,etal.;J.Antibiot.23,442(1970)
- Inhibitionofc-mycgeneexpressioninmurinelymphoblastomacellsbygeldanamycinandherbimycin,antibioticsofbenzoquinoidansamycingroup:H.Yamaki,etal.;J.Antibiot.42,604(1989)
- Geldanamycinselectivelydestabilizesandconformationallyaltersmutatedp53:M.V.Blagosklonny,etal.;Oncogene11,933(1995)
- Inhibitionoftheoncogeneproductp185erbB-2invitroandinvivobygeldanamycinanddihydrogeldanamycinderivatives:R.C.Schnur,etal.;J.Med.Chem.38,3806(1995)
- Stableandspecificbindingofheatshockprotein90bygeldanamycindisruptsglucocorticoidreceptorfunctioninintactcells:L.Whitesell&P.Cook;Mol.Endocrinol.10,705(1996)
- Geldanamycinasapotentialanti-canceragent:itsmoleculartargetandbiochemicalactivity:L.Neckers,etal.;Invest.NewDrugs17,361(1999),(Review)
- Hsp-90-associatedoncoproteins:multipletargetsofgeldanamycinanditsanalogs:M.V.Blagosklonny;Leukemia16,455(2002),(Review)
- GeldanamycinenhanceshepatocytegrowthfactorstimulationofeNOSphosphorylationinendothelialcells:K.Makondo,etal.;Eur.J.Pharmacol.582,110(2007)
- HSP90antagoNIST,geldanamycin,inhibitsproliferation,inducesapoptosisandblocksmigrationofrhaBDomyosarcomacellsinvitroandseedingintobonemarrowinvivo:E.Lesko,etal.;AnticancerDrugs18,1173(2007)
- Inhibitionofheatshockprotein90impairsepidermalgrowthfactor-mediatedsignalingingastriccancercellsandreducestumorgrowthandvascularizationinvivo:S.A.Lang,etal.;Mol.CancerTher.6,1123(2007)
- Lowdosegeldanamycininhibitshepatocytegrowthfactorandhypoxia-stimulatedinvasionofcancercells:F.Koga,etal.;CellCycle6,1393(2007)
- Hsp90-inhibitorgeldanamycinabrogatesG(2)arrestinp53-negativeleukemiacelllinesthroughthedepletionofChk1:K.Sugimoto,etal.;Oncogene27,3091(2008)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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