Adipogen/Gardiquimod/AG-CR1-3583-M025/25 mg
商品编号：
AG-CR1-3583-M025
品牌：
Adipogen Inc
市场价：
¥3300.00
美元价：
1980.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 1-(4-Amino-2-ethylaminomethylimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol |
| ProductType | Chemical |
| Properties | |
| Formula | C17H23N5O |
| MW | 313.4 |
| CAS | 1020412-43-4 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitepowder. |
| Solubility | SolubleinDMSO,dioxane,methanoloracetonitrile. |
| InChiKey | FHJATBIERQTCTN-DZQCGVKKCV |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Stocksolutionsarestableforatleast3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Immuneresponsemodifier.
- Antiviralandantitumorcompound
- SelectiveligandforhumanormouseToll-likereceptor7(TLR7).
- InducestheactivationofNF-κBinHEK293cellsexpressingTLR7at0.1µg/ml.10timesmoreactivethanImiquimod(Prod.No.AG-CR1-3569).
- Athighconcentrations(3µg/ml)slightlyactivatesTLR8.
- Showsadjuvantactivitytoincreasetheeffectivenessofvaccines.
ProductReferences
- Double-StrandedRNAInducesanAntiviralDefenseStatusinEpidermalKeratinocytesthroughTLR3-,PKR-,andMDA5/RIG-I-MediatedDifferentialSignaling:B.N.Kalali,etal.;J.Immunol.181,2694(2008)
- PorcineTLR8andTLR7arebothactivatedbyaselectiveTLR7ligand,imiquimod:J.Zhu,etal.;Mol.Immunol.45,3238(2008)
- Regioisomerism-dependentTLR7agonismandantagonisminanimidazoquinoline:N.M.Shukla,etal.;Bioorg.Med.Chem.Lett.19,2211(2009)
- IntradermalimmunizationimprovesprotectiveefficacyofanovelTBvaccinecandidate:S.L.Baldwin,etal;Vaccine27,3063(2009)
- SignalingthroughTLR7enhancestheimmunosuppressiveactivityofmurineCD4+CD25+Tregulatorycells:N.A.Forward,etal.;J.Leukoc.Biol.87,117(2010)
- TheTLR7agoNISTsimiquimodandgardiquimodimproveDC-basedimmunotherapyformelanomainmice:F.Ma,etal.;CellMol.Immunol.7,381(2010)
- TLR8agonistsstimulatenewlyrecruitedmonocyte-derivedcellsintopotentAPCsthatenhanceHBsAgimmunogenicity:J.Du,etal.;Vaccine28,6273(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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