脂肪原/神经节苷脂GT1b。三钠盐/AG-CN2-9006-M005/5 mg
商品编号：
AG-CN2-9006-M005
品牌：
Adipogen Inc
市场价：
¥6000.00
美元价：
3600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | GT1b.3Na;TrisialogangliosideGT1b.3Na |
| ProductType | Chemical |
| Properties | |
| Formula | C95H162N5O47.3Na |
| MW | 2126.3.69.0(calculatedonsphingosine C18:1andstearicacid) |
| Sequence | Structure:IV3Neu5AcII3NeuAc2GgOse4Cer;α-Neu5Ac-(2-3)-β-Gal-(1-3)-β-GalNAc-(1-4)-[α-Neu5Ac-(2-8)-α-Neu5Ac-(2-3)-]β-Gal-(1-4)-β-Glc-(1-1)-Cer;Cer:SphingosineC18:1-C20:1,~1:1byvol.;stearicacidover90% |
| CAS | 59247-13-1 |
| Source/HostChemicals | Isolatedfrombovinebrain. |
| PurityChemicals | ≥98%(TLC) |
| Solubility | Solubleinwater(micellaraggregates)orchloroform:methanol(2:1). |
| Formulation | Lyophilized |
| EndotoxinContent | Notdetectable. |
| Identity | Determinedby1H-NMR,MSandHPTLC. |
| InChiKey | XWMACUIMZLECSZ-UVHDICHMSA-K |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Hygroscopic. Protectfrommoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Gangliosidesareacidicglycosphingolipidsthatformlipidraftsintheouterleafletofthecellplasmamembrane,especiallyinneuronalcellsinthecentralnervoussystem.Theyparticipateincellularproliferation,differentiation,adhesion,signaltransduction,cell-to-cellinteractions,tumOrigenesisandmetastasis.Theaccumulationofgangliosideshasbeenlinkedtoseveraldiseases.GangliosideGT1bbindsbotulinumandtetanusneurotoxinsanditpreventsneurotoxicityofglutamateonneuronalcells.
ProductReferences
- Roleofmembranegangliosidesinthebindingandactionofbacterialtoxins:P.H.Fishman;J.Membr.Biol.69,85(1982).
- BindingofbotulinumandtetanusneurotoxinstogangliosideGT1bandderivativesthereof:C.L.Schengrund,etal.;J.NeuRochem.57,1024(1991)
- Dynamicandstructuralpropertiesofsphingolipidsasdrivingforcetotheformationofmembranedomains:S.Sonnino,etal.;Chem.Rev.106,2111(2006)
- InvolvementofgangliosideGT1binglutamatereleasefromneuroblastomacells:S.Watanabe,etal.;Neurosci.Lett.517,140(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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