Adipogen/Ganglioside GD3 . disodium salt/AG-CN2-9005-M001/1 mg
商品编号：
AG-CN2-9005-M001
品牌：
Adipogen Inc
市场价：
¥5800.00
美元价：
3480.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | GD3 . 2Na; Disialoganglioside GD3 . 2Na |
| Product Type | Chemical |
| Properties | |
| Formula | C70H123N3O29 . 2Na |
| MW |
1470.8 . 46.0 (calculated on sphingosine C18:1 and stearic acid) |
| Sequence | Structure: α-Neu5Ac-(2-8)-α-Neu5Ac-(2-3)-β-Gal-(1-4)-β-Glc-(1-1)-Cer; Cer: Sphingosine C18:1-C20:1, ~1:1 by vol.; stearic acid over 90% |
| CAS | 62010-37-1 |
| Source/Host Chemicals | Isolated from bovine brain. |
| Purity Chemicals | ≥98% (TLC) |
| Solubility | Soluble in water or chloroform:methanol (2:1). |
| Formulation | Lyophilized. |
| Endotoxin Content | Not detectable. |
| Identity | Determined by 1H-NMR, MS and HTPLC. |
| InChi Key | LGRBZCLULGFXOD-MIJDSYIJSA-L |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Hygroscopic. Protect from moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD3 induces mitochondrial permeability transition (MPT) without requiring elevated Ca2+ levels and thus triggers Fas-mediated apoptosis. It modulates the activity of Src-family tyrosine kinase Lyn and cell apoptosis. It is involved in several tumor processes and is high abundant in proliferating cells and in the first stage of neuronal differentiation.
Product References
- Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982)
- Gangliosides and neuronal differentiation: H. Rosner, et al.; Neurochem. Int. 20, 339 (1992)
- Ganglioside GD3 as a raft component in cell death regulation: M. Sorice, et al.; Anticancer Agents Med. Chem. 12, 376 (2012)
- Involvement of gangliosides in the process of Cbp/PAG phosphorylation by Lyn in developing cerebellar growth cones: N. Sekino-Suzuki, et al.; J. Neurochem. 124, 514 (2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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