Adipogen/G418 . sulfate/AG-CN2-0030-G005/5 g
商品编号：
AG-CN2-0030-G005
品牌：
Adipogen Inc
市场价：
¥3100.00
美元价：
1860.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Geneticin; Antibiotic G418; BRN 1669188 |
| Product Type | Chemical |
| Properties | |
| Formula | C20H40N4O10 . 2H2SO4 |
| MW | 496.6 . 196.1 |
| CAS | 108321-42-2 |
| RTECS | CB9378500 |
| Source/Host Chemicals | Isolated from Micromonospora rhodorangea. |
| Purity Chemicals | ≥98% (TLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in water (up to 50 mg/ml). |
| Biological Activity |
Assay: ≥700 μg/mg Biological Assay: ED50 Resistant: ≥2500 μg/ml Biological Assay: ED50 Sensitivity: ≤400 μg/ml |
| InChi Key | BRZYSWJRSDMWLG-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Antibiotic [1].
- Cytotoxic to prokaryotic and eukaryotic cells by inhibiting the protein synthesis [1, 3, 4, 6].
- Apoptosis inducer [5].
- Widely employed in the selection of eukaryotic expression vectors, in combination with either aminoglycoside phosphotransferase 3' or APH II [2].
- Antiviral [7, 8].
Product References
- Antibiotic G-418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminths: fermentation, isolation, and preliminary characterization: G.H. Wagman, et al.; Antimicrob. Agents Chemother. 6, 144 (1974)
- Phosphatidylinositol phospholipase C is activated allosterically by the aminoglycoside G418. 2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecylphosphonate and its analogs inhibit glycosylphosphatidylinositol phospholipase C: J.C. Morris, et al.; J. Biol. Chem. 271, 15468 (1996)
- Addition of G418 and other aminoglycoside antibiotics to mammalian cells results in the release of GPI-anchored proteins: M. Kung, et al.; FEBS Lett. 409, 333 (1997)
- The effects of G418 on the growth and metabolism of recombinant mammalian cell lines: C.A. Yallop & I. Svendsen; Cytotechnology 35, 101 (2001)
- Cytochrome c release and endoplasmic reticulum stress are involved in caspase-dependent apoptosis induced by G418: Q.H. Jin, et al.; Cell. Mol. Life Sci. 61, 1816 (2004)
- Expression and distribution of HSP27 in response to G418 in different human breast cancer cell lines: L. Qian, et al.; Histochem. Cell Biol. 126, 593 (2006)
- Antiviral activity of geneticin against bovine viral diarrhoea virus: A.V. Birk, et al.; Antivir. Chem. Chemother. 19, 33 (2008)
- Antiviral activity of geneticin against dengue virus: X.G. Zhang, et al.; Antiviral Res. 83, 21 (2009)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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