Adipogen/Fumagillin (high purity)/BVT-0424-M005/5 mg
商品编号：
BVT-0424-M005
品牌：
Adipogen Inc
市场价：
¥5600.00
美元价：
3360.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Amebacilin;Fugilin;Fumidil;FumADIlB;NSC9168;U5762 |
| ProductType | Chemical |
| Properties | |
| Formula | C26H34O7 |
| MW | 458.6 |
| MerckIndex | 14:4286 |
| CAS | 23110-15-8 |
| RTECS | HE1750000 |
| Source/HostChemicals | IsolatedfromAspergillusfumigatus(StrainWDMH-35). |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Off-whitesolid. |
| Solubility | SolubleinDMSO,acetoneorchloroform.Slightlysolubleinmethanolorethanol.Insolubleinwater. |
| Identity | Determinedby1H-NMRandMS. |
| Declaration | ManufacturedbyBioViotica. |
| InChiKey | NGGMYCMLYOUNGM-IWMBURASSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Meroterpenoidantibiotic.
- Anticancer,antimicrobial,antimalarialandamoebicidalcompound.Potent,selectiveandcovalentinhibitorofmethionineaminopeptidase-2(MetAP2).
- Anti-angiogenicbyimpairingthegrowthofendothelialcellsandalteringgeneexpression.
- Inhibitsendothelialcellproliferationinvitroandtumor-inducedangiogenesisinvivo.
- SuppressestheHIV-1infectionofhumanmacrophagesthroughtheinhibitionofHIV-1viralproteinR(Vpr)activity.
- Inhibitsneovascularizationandmightbeusefulinnon-tumordiseasessuchasdiabeticretinopathy,arthritisandpsoriasis,whichinvolveneovascularisationprocesses.
- Reducesdiet-inducedadiposetissueformationinmice,independentofitseffectsonangiogenesis.
ProductReferences
- AntibioticsubstanceproducedbyAspergillusfumigatus:T.E.Eble,etal.;Antibiot.Chemother.1,54(1951)
- Syntheticanaloguesoffumagillinthatinhibitangiogenesisandsuppresstumourgrowth:D.Ingber,etal.;Nature348,555(1990)
- Theanti-angiogenicagentfumagillincovalentlybindsandinhibitsthemethionineaminopeptidase,MetAP-2:N.Sin,etal.;PNAS94,6099(1997)
- InhibitionofAngiogenesisInVivobyets-1AntisenseOligonucleotides-InhibitionofEts-1TranscriptionFactorExpressionbytheAntibioticFumagillin:N.Wernert,etal.;Angew.Chem.Int.Ed.Engl.38,3228(1999)
- Structureelucidationoffumagillin-relatednaturalproducts:J.Halasz,etal.;Tetrahedron56,10081(2000)
- Are-evaluationoffumagillinselectivitytowardsendothelialcells:S.Rodriguez-Nieto,etal.;AnticancerRes.21,3457(2001)
- Fumagillintreatmentofintestinalmicrosporidiosis:J.Molina,etal.;N.Engl.J.Med.346,1963(2002)
- Earlygeneticmechanismsunderlyingtheinhibitoryeffectsofendostatinandfumagillinonhumanendothelialcells:C.M.Mazzanti,etal.;GenomeRes.14,1585(2004)
- FumagillinsuppressesHIV-1infectionofmacrophagesthroughtheinhibitionofVpractivity:N.Watanabe,etal.;FEBSLett.580,2598(2006)
- Fumagillin:ananti-infectiveasaparentmoleculefornovelangiogenesisinhibitors:B.Lefkove,etal.;ExpertRev.Anti-Infect.Ther.5,573(2007)
- FumagillinandfumarranolinteractwithP.falciparummethionineaminopeptidase2andinhibitmalariaparasitegrowthinvitroandinvivo:X.Chen,etal.;Chem.Biol.16,193(2009)
- Fumagillininhibitscolorectalcancergrowthandmetastasisinmice:invivoandinvitrostudyofanti-angiogenesis:L.Hou,etal.;Pathol.Int.59,448(2009)
- Synthesesoffumagillinandovalicin:J.Yamaguchi&Y.Hayashi;Chem.Eur.J.16,3884(2010)
- Fumagillinreducesadiposetissueformationinmurinemodelsofnutritionallyinducedobesity:H.R.Lijnen,etal.;Obesity18,2241(2010)
- InhibitionofneutrophilfunctionfollowingexposuretotheAspergillusfumigatustoxinfumagillin:J.P.Fallon,etal.;J.Med.Microbiol.59,625(2010)
- Fumagillinandstructurallyrelatedmoleculesassourceofnewdrugs:D.Gamba-Sanches;Mini-Rev.Org.Chem.9,126(2012)
- Stimulationofsuicidalerythrocytedeathbyfumagillin:M.Zbidah,etal.;BasicClin.Pharmacol.Toxicol.112,346(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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