Adipogen/FTY720 . hydrochloride/AG-CR1-3587-M025/25 mg
商品编号：
AG-CR1-3587-M025
品牌：
Adipogen Inc
市场价：
¥760.00
美元价：
456.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms |
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol . HCl; Fingolimod; Gilenya |
| Product Type | Chemical |
| Properties | |
| Formula | C19H33NO2 . HCl |
| MW | 307.4 . 36.5 |
| CAS | 162359-56-0 |
| RTECS | TY3130000 |
| Source/Host Chemicals | Synthetic analog of ISP-1, isolated from Isaria sinclairii. |
| Purity Chemicals | ≥98% |
| Appearance | White solid. |
| Solubility | Soluble in DMSO, ethanol or DMF. |
| InChi Key | SWZTYAVBMYWFGS-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis [1, 6].
- Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase [2,4].
- Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer [3].
- Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors [5].
- Autophagy inducer [7].
- Apoptosis inducer [8].
Product References
- FTY720: Altered lymphocyte traffic results in allograft protection: V. Brinkmann, et al.; Transplantation 72, 764 (2001)
- The immune modulator FTY720 targets sphingosine 1-phosphate receptors: V. Brinkmann, et al.; J. Biol. Chem. 277, 21453 (2002)
- FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes: S.M. Honig, et al.; J. Clin. Invest. 111, 627 (2003)
- Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1: M. Matloubian, et al.; Nature 427, 355 (2004)
- The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors: S.G. Payne, et al.; Blood 109, 1077 (2007)
- Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite: C.R. Strader, et al.; J. Nat. Prod. 74, 900 (2011)
- Autophagy induced by FTY720 promotes apoptosis in U266 cells: A. Liao, et al.; Eur. J. Pharm. Sci. 45, 600 (2012)
- Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma: A. Estrada-Bernal, et al.; Neuro Oncol. 14, 405 (2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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