Adipogen/Forskolin/AG-CN2-0089-M050/50 mg
商品编号：
AG-CN2-0089-M050
品牌：
Adipogen Inc
市场价：
¥2200.00
美元价：
1320.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Boforsin;Colforsin;Coleonol;NSC357088;NSC375489 |
| ProductType | Chemical |
| Properties | |
| Formula | C22H34O7 |
| MW | 410.5 |
| MerckIndex | 14:2476 |
| CAS | 66428-89-5and66575-29-9 |
| Source/HostChemicals | IsolatedfromColeusforskohlii. |
| PurityChemicals | ≥99%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | Solubleinethylacetate,anhydrousDMSOorethanol;verypoorlysolubleinwater.DMSOistherecommendedsolventforactivationofcAMP. |
| Identity | Determinedby1H-NMR. |
| OtherProductData | Note:Donotdissolveinethanolforactivationofadenylylcyclase. |
| InChiKey | OHCQJHSOBUTRHG-KGGHGJDLSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potent,cellpermeableadenylylcyclaseactivator.IncreasesintracellularcAMPlevels[1,2,6].
- WidelyusedtooltoinvestigatecAMPasasecondmessenger[15].
- Inotropicandantihypertensive.Smoothmusclerelaxant/vasodilator[3,4,6].
- Glucosetransporterinhibitor[4].
- Plateletaggregationinhibitor[3,10].
- Stimulateslipolysisinfatcells[8].
- Non-competitivenicotinicacetylcholinereceptorsinhibitor[9].
- MAPkinaseinhibitor[11].
- Upregulatesmitochondrialuncouplingprotein(UCP)mRNAlevelsinbrownADIposetissue[12].
- Autophagyinhibitor[13].
- Hedgehogsignalinginhibitor[14].
- Hasantiglaucomapotential[16].
- PromotesneuronaldifferentiationofNSCs [17].
ProductReferences
- Thepositiveinotropic-actingforskolin,apotentadenylatecyclaseactivator:H.Metzger&E.Lindner;Arzneimittelforschung31,1248(1981)
- Forskolin:auniquediterpeneactivatorofcyclicAMP-generatingsystems:K.B.Seamon&J.W.Daly;J.CyclicNucleotideRes.7,201(1981)
- Forskolin:alaBDanediterpenoidwithantihypertensive,positiveinotropic,plateletaggregationinhibitory,andadenylatecyclaseactivatingproperties:N.J.deSouza,etal.;Med.Res.Rev.3,201(1983)
- Effectsofforskolinoncerebralbloodflow:Implicationsforaroleofadenylatecyclase:D.G.Wysham,etal.;Stroke17,1299(1986)
- Forskolininhibitsinsulin-stimulatedglucosetransportinratadiposecellsbyadirectinteractionwiththeglucosetransporter:H.G.Joost&H.J.Steinfelder;Mol.Pharmacol.31,279(1987)
- EffectofforskolinoncytosolicCa++levelandcontractioninvascularsmoothmuscle:A.Abe&H.Karaki;J.Pharmacol.Exp.Ther.249,895(1989)
- Forskolin:aspecificstimulatorofadenylylcyclaseoraditerpenewithmultiplesitesofaction?:A.Laurenza,etal.;TIPS10,442(1989)(Review)
- RelationshipbetweencyclicAMPproductionandlipolysisinducedbyforskolininratfatcells:H.Okuda,etal.;J.LipidRes.33,225(1992)
- Forskolinactsasanoncompetitiveinhibitorofnicotinicacetylcholinereceptors:M.L.Aylwin&M.M.White;Mol.Pharmacol.41,908(1992)
- Forskolininhibitsplatelet-activatingfactorbindingtoplateletreceptorsindependentlyofadenylylcyclaseactivation:S.Wong,etal.;Eur.J.Pharmacol.245,55(1993)
- ForskolininhibitsproteinkinaseC-inducedmitogenactivatedproteinkinaseactivityinMC3T3-E1osteoblasts:S.R.Siddhanti,etal.;Endocrinol.136,4834(1995)
- Thermogenesisinbrownadiposetissuewithage:post-receptoractivationbyforskolin:P.J.Scarpace&M.Matheny;PflugersArch.431,388(1996)
- Roleoftheautophagic-lysosomalsystemonlowpotassium-inducedapoptosisinculturedcerebellargranulecells:N.Canu,etal.;J.NeuRochem.92,1228(2005)
- Forskolin,aHedgehogsignalinhibitor,inhibitscellproliferationandinducesapoptosisinpediatrictumorcelllines:H.Yamanaka,etal.;Mol.Med.Rep.3,133(2010)
- ForskolinandderivativesastoolsforstudyingtheroleofcAMP:R.H.Alasbahi&M.F.Melzig;Pharmazie67,5(2012)(Review)
- Forskolin:upcomingantiglaucomamolecule:V.D.Wagh,etal.;J.Postgrad.Med.58,199(2012)(Review)
- Functionalneuraldifferentiationofhumanadiposetissue-derivedstemcellsusingbFGFandforskolin:S.Jang,etal.;BMCCellBiol.11,1(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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