Adipogen/FK-866/AG-CR1-0011-M001/1 mg
商品编号：
AG-CR1-0011-M001
品牌：
Adipogen Inc
市场价：
¥800.00
美元价：
480.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | K 22.175; FK866; APO866; WK175; N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide |
| Product Type | Chemical |
| Properties | |
| Formula | C24H29N3O2 |
| MW | 391.5 |
| CAS | 658084-64-1 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to yellow solid. (Tends to easily liquefy.) |
| Solubility | Soluble in 100% ethanol, dimethylformamide (40 mg/ml) or DMSO (25 mg/ml); sparingly soluble in aqueous buffers. |
| InChi Key | KPBNHDGDUADAGP-VAWYXSNFSA-N |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Hygroscopic. Keep under inert gas. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Nampt/visfatin inhibitor [1].
- Inhibitor of NAD+ biosynthesis [1].
- Inhibits the enzyme/substrate complex and the free enzyme (Ki = 0.4 nM and Ki = 0.3 nM, respectively) [1].
- Apoptosis inducer [1].
- Autophagy inducer [2].
- Causes premature senescence [3].
- Angiogenesis inhibitor [4].
Product References
- FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis: M. Hasmann & I. Schemainda; Cancer Res. 63, 7436 (2003)
- NAD depletion by FK866 induces autophagy: R.A. Billington, et al.; Autophagy 4, 385 (2008)
- Extension of human cell lifespan by nicotinamide phosphoribosyltransferase: E. van der Veer, et al.; J. Biol. Chem. 282, 10841 (2007)
- Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma: J. Drevs, et al.; Anticancer Res. 23, 4853 (2003)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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