Adipogen/FK-506/AG-CN2-0047-M005/5 mg
商品编号：
AG-CN2-0047-M005
品牌：
Adipogen Inc
市场价：
¥1200.00
美元价：
720.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Tacrolimus;Fujimycin |
| ProductType | Chemical |
| Properties | |
| Formula | C44H69NO12.H2O |
| MW | 804.0.18.0 |
| MerckIndex | 14:9025 |
| CAS | 109581-93-3 |
| RTECS | KD4200000 |
| Source/HostChemicals | IsolatedfromStreptomycesFCZ0311. |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO,ethanol,methanol,ethylacetateoracetone.Insolubleinwater. |
| Identity | DeterminedbyMSandIR. |
| InChiKey | NWJQLQGQZSIBAF-CBLXODBSSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentimmunosuppressant(ascyclosporinAandrapamycin)[1-3].
- SuppressesproliferationofcytotoxicTcellsandinhibitstheproductionofTcell-derivedmediatorssuchasinterleukin-2(IL-2)[2,4].
- FormsacomplexwithFK-506bindingprotein12(FKBP12).Inhibitstheactivityofthecalcium/calmodulin-dependentproteinphosphatase2B(PP2B;calcineurin),leADIngtodisruptionofTcellactivation[2,4,6,7].
- Preventsrejectionoftransplantedorgans[3].
- Anti-inflammatorycompoundinthetreatmentofseveralinflammatoryskindiseases(e.g.atopicdermatitis)andwithpotentialanti-rheumaticactivity(rheumatoidarthritis)[5,9].
- Neuroprotective.Regulatesnitricoxideneurotoxicity.Neurotransmitter.Ca2+releasecompound[8].
- NF-κBsuppressorbyinductionofunfoldedproteinresponse(UPR)[11].
- Anti-cancercompound.Apoptosisinducer[10,12].
ProductReferences
- FK-506,anovelimmunosuppressantisolatedfromaStreptomyces.I.Fermentation,isolation,andphysico-chemicalandBIOLOGicalcharacteristics:T.Kino,etal.;J.Antibiot.(Tokyo)40,1249(1987)
- CyclosporinA,FK506andrapamycin:morethanjustimmunosuppression:J.Kunz&M.N.Hall;TIBS18,334(1993)
- CyclosporinAandFK506:molecularmechanismsofimmunosuppressionandprobesfortransplantationbiology:B.E.Bierer,etal.;Curr.Opin.Immunol.5,763(1993)
- TheactionsofcyclosporinAandFK506onT-lymphocyteactivation:P.S.Mattila;Biochem.Soc.Trans.24,45(1996)(Review)
- FK506inthetreatmentofinflammatoryskindisease:promisesandperspectives:G.Michel,etal.;Immunol.Today17,106(1996)(Review)
- ThemechanismofactionofcyclosporinAandFK506:S.Ho,etal.;Clin.Immunol.Immunopathol.80,S40(1996)(Review)
- FK506,animmunosuppressanttargetingcalcineurinfunction:F.J.Dumont;Curr.Med.Chem.7,731(2000)(Review)
- FK506anditsanalogs-therapeuticpotentialforneurologicaldisorders:A.Klettner&T.Herdegen;Curr.DrugTargetsCNSNeurol.Disord.2,153(2003)(Review)
- Areviewoftheactionoftacrolimus(FK506)onexperimentalmodelsofrheumatoidarthritis:S.Miyata,etal.;Inflamm.Res.54,1(2005)(Review)
- Metabolismoftacrolimus(FK506)andrecenttopicsinclinicalpharmacokinetics:K.Iwasaki;DrugMetab.Pharmacokinet.22,328(2007)(Review)
- SuppressionofNF-kappaBbycyclosporinAandtacrolimus(FK506)viainductionoftheC/EBPfamily:implicationforunfoldedproteinresponse:S.Du,etal.;J.Immunol.182,7201(2009)
- FK506bindingproteinsastargetsinanticancertherapy:S.Romano,etal.;AnticancerAgentsMed.Chem.10,651(2010)(Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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