脂肪原/EPZ-6438/SYN-3045-M050/50毫克
商品编号：
SYN-3045-M050
品牌：
Adipogen Inc
市场价：
¥5400.00
美元价：
3240.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Tazemetostat;E7438 |
| ProductType | Chemical |
| Properties | |
| Formula | C34H44N4O4 |
| MW | 572.8 |
| CAS | 1403254-99-8 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:EZH2|KinaseGroup:N/A|Substrate:N/A ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | NSQSAUGJQHDYNO-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
EPZ6438isapotentorallybioavailable,selectiveinhibitorofthelysinemethyltranferaseEZH2(Ki=2.5nM),theenzymaticsubunitofpolycombrepressivecomplexItdisplaysa35-foldselectivityversusEZH1and>4,500-foldselectivityrelativeto14otherhistonemethyltransferases.EPZ6438blockshistoneH3lysine27trimethylationinbothwild-typeandmutantlymphomacells(IC50 rangefrom2-90nM).EPZ6438hasbeenshowntoinduceapoptosisanddifferentiationspecificallyinSMARCB1-deletedmalignantrhaBDoidtumor(MRT)cellsandtopromotetheirregressioninxenograft-bearingmice.
ProductReferences
- DurabletumorregressioningeneticallyalteredmalignantrhabdoidtumorsbyinhibitionofmethyltransferaseEZH2:S.K.Knutson,etal.;PNAS110,7922(2013)
- SelectiveinhibitionofEZH2byEPZ-6438leadstopotentantitumoractivityinEZH2-mutantnon-Hodgkinlymphoma:S.K.Knutson,etal.;Mol.CancerTher.13,842(2014)
- SynergisticAnti-TumorActivityofEZH2InhibitorsandGlucocorticoidReceptorAgoNISTsinModelsofGerminalCenterNon-HodgkinLymphomas:S.K.Knutson,etal.;PLoSOne9,e111840(2014)
- EZH2promotescolorectalcancerstem-likecellexpansionbyactivatingp21cip1-Wnt/β-cateninsignaling:J.F.chen,etal.;Oncotarget(Epubaheadofprint)(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
