Adipogen/Epoxomicin/AG-CN2-0422-C100/100 µg
商品编号：
AG-CN2-0422-C100
品牌：
Adipogen Inc
市场价：
¥2400.00
美元价：
1440.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AntibioticBU4061T |
| ProductType | Chemical |
| Properties | |
| Formula | C28H50N4O7 |
| MW | 554.7 |
| MerckIndex | 14:3630 |
| CAS | 134381-21-8 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥97%(NMR) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO.Insolubleinwater. |
| InChiKey | DOGIDQKFVLKMLQ-JTHVHQAWSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic[1].
- Potentanticancercompound[1,7].
- Cellpermeable,potent,selectiveandirreversIBLe20Sproteasomeinhibitor.Predominantlyinhibitsthechymotrypsin-like(CTRL)activityoftheproteasome.Exhibitslowerlevelinhibitionofproteasometrypsin-likeandcaspase-likeactivitives(100and1,000-foldslowerratesrespectively)[2,3].
- Anti-inflammatory[4].
- Antimicrobialandantimalarial[8].
- Anti-parasitic[9].
- Stimulatesboneformationbyinhibitingosteoblastproteasomeactivity[5].
- InducesParkinson"s-likesymptomsinrats[6].
- Theubiquitin-proteasomesystem(UPS)andautophagyserveastwocomplementary,reciprocallyregulatedproteindegradationsystems.BlockadeofUPSbyEpoxomicinactivatesautophagy.
- BlockstheThymoproteasomeβ5tsubunitactivity.
ProductReferences
- Epoxomicin,anewantitumoragentofmicrobialorigin:M.Hanada,etal.;J.Antibiot.45,1746(1992)
- Totalsynthesisofthepotentproteasomeinhibitorepoxomicin:ausefultoolforunderstandingproteasomeBIOLOGy:N.Sin,etal.;Bioorg.Med.Chem.Lett.9,2283(1999)
- Proteasomeinhibitionbythenaturalproductsepoxomicinanddihydroeponemycin:insightsintospecificityandpotency:K.B.Kim,etal.;Bioorg.Med.Chem.Lett.9,3335(1999)
- Epoxomicin,apotentandselectiveproteasomeinhibitor,exhibitsinvivoantiinflammatoryactivity:L.Meng,etal.;PNAS96,10403(1999)
- Selectiveinhibitorsoftheosteoblastproteasomestimulateboneformationinvivoandinvitro:I.R.Garrett,etal.;J.Clin.Invest.111,1771(2003)
- SystemicexposuretoproteasomeinhibitorscausesaprogressivemodelofParkinson"sdisease:K.S.McNaught,etal.;Ann.Neurol.56,149(2004)
- Establishmentandsomecharacteristicsofepoxomicin(aproteasomeinhibitor)resistantvariantsofthehumansquamouscellcarcinomacellline,A431:K.Ohkawa,etal.;Int.J.Oncol.24,425(2004)
- TheproteasomeinhibitorepoxomicinhaspotentPlasmodiumfalciparumgametocytocidalactivity:B.Czesny,etal.;Antimicrob.AgentsChemother.53,4080(2009)
- Evaluationoftheinvitrogrowth-inhibitoryeffectofepoxomicinonBabesiaparasites:M.Aboulaila,etal.;Vet.Parasitol.167,19(2010)
- Mechanismsofcross-talkbetweentheubiquitin-proteasomeandautophagy-lysosomesystems:V.I.Korolchuk,etal.;FEBSLett.584,1393(2010)
- Activity-BasedProfilingRevealsReactivityoftheMurineThymoproteasome-SpecificSubunitβ5t:B.I.Florea,etal.;Chem.Biol.17,795(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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