Adipogen/Epacadostat/AG-CR1-3634-M005/5 mg
商品编号：
AG-CR1-3634-M005
品牌：
Adipogen Inc
市场价：
¥2400.00
美元价：
1440.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | INCB24360;(E)-N’-(3-Bromo-4-fluorophenyl)-N-hydroxy-4-((2-(sulfamoylamino-1,2,5-oxADIazole-3-carboxamide) |
| ProductType | Chemical |
| Properties | |
| Formula | C11H13BrFN7O4S |
| MW | 438.2 |
| CAS | 1204669-58-8 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO(~30mg/ml).Insolubleinwater. |
| InChiKey | FBKMWOJEPMPVTQ-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Keepunderinertgas. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentandselectivecompetitiveindoleamine2,3-dioxygenase(IDO1)inhibitor.InhibitsIDO1inenzymatic(IC50=72nM)andincellulartests(IC50=7.1nM),suppressestryptophancatabolisminvivoandimpedestumorgrowth.DisplayshighselectivityoverotherrelatedenzymessuchasIDO2ortryptophan2,3-dioxygenase(TDO).
- Exhibitspotentinvitroandinvivoimmunomodulatingandantineoplasticactivities.
- ByinhibitingIDO1anddecreasingkynureninelevelsintumorcells,Epacadostatincreasesandrestorestheproliferationandactivationofvariousimmunecells,includingdendriticcells(DCs),NKcellsandT-lymphocytes,aswellasinterferon(IFN)productionandreducestumor-associatedregulatoryTcells(Tregs).
ProductReferences
- Hydroxyamidineinhibitorsofindoleamine-2,3-dioxygenasepotentlysuppresssystemictryptophancatabolismandthegrowthofIDO-expressingtumors:H.K.Koblish,etal.;Mol.CancerTher.9,489(2010)
- SelectiveinhibitionofIDO1effectivelyregulatesmediatorsofantitumorimmunity:X.Liu,etal.;Blood115,3520(2010)
- Trialwatch:IDOinhibitorsincancertherapy:E.Vacchelli,etal.;Oncoimmunology3,e957994(2014)
- ChallengesintheDiscoveryofIndoleamine2,3-Dioxygenase1(IDO1)Inhibitors:U.F.Roehrig,etal.;J.Med.Chem.58,9421(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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