Adipogen/Empagliflozin/AG-CR1-3619-M050/50 mg
商品编号：
AG-CR1-3619-M050
品牌：
Adipogen Inc
市场价：
¥3600.00
美元价：
2160.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Jardiance;BI-10773;(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol |
| ProductType | Chemical |
| Properties | |
| Formula | C23H27ClO7 |
| MW | 450.9 |
| CAS | 864070-44-0 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO.Slightlysolubleinwaterorethanol. |
| Identity | Determinedby1H-NMR. |
| InChiKey | OBWASQILIWPZMG-QZMOQZSNSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast3yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antidiabeticagent.
- Potentandselectivesodiumglucoseco-transporter2(SGLT-2)inhibitor.>300-foldselectivityoverSGLT-1,4,5and6.
- SGLT-2isfoundalmostexclusivelyintheproximaltubulesofnephroniccomponentsinkidneys.InhibitionofSGLT-2reducesbloodglucosebyblockingrenalglucosereabsorptionandtherebyincreasingurinaryglucoseexcretion(UGE).
- Showntopreservesβcellmassandrestoreglucosehomeostasis.
ProductReferences
- BI-10773,asodium-glucosecotransporter2inhibitorforthepotentialoraltreatmentoftype2diabetesmellitus:I.Aires&J.Calado;Curr.Opin.Investig.Drugs11,1182(2010)
- Empagliflozin,anovelselectivesodiumglucosecotransporter-2(SGLT-2)inhibitor:characterisationandcomparisonwithotherSGLT-2inhibitors:R.Grempler,etal.;DiabetesObes.Metab.14,83(2012)
- Long-termtreatmentwithempagliflozin,anovel,potentandselectiveSGLT-2inhibitor,improvesglycaemiccontrolandfeaturesofmetabolicsyndromeindiabeticrats:L.Thomas,etal.;DiabetesObes.Metab.14,94(2012)
- Empagliflozin(BI10773),apotentandselectiveSGLT2inhibitor,inducesdose-dependentglucosuriainhealthysubjects.L.Seman,etal.;Clin.Pharmacol.DrugDev.2,152(2013)
- TheSGLT2InhibitorEmpagliflozinfortheTreatmentofType2DiabetesMellitus:aBenchtoBedsideReview:J.B.McGill;DiabetesTher.5,43(2014)(Review)
- Empagliflozin,asodiumglucoseco-transporter2inhibitor,inthetreatmentoftype1diabetes:E.M.Lamos,etal.;ExpertOpin.Investig.Drugs23,875(2014)(Review)
- Thesodiumglucosecotransportertype2inhibitorempagliflozinpreservesβ-cellmassandrestoresglucosehomeostasisinthemalezuckerdiabeticfattyrat:H.H.Hansen,etal.;J.Pharmacol.Exp.Ther.350,657(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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