Adipogen/EM574/AG-CN2-0102-C250/250 µg
商品编号：
AG-CN2-0102-C250
品牌：
Adipogen Inc
市场价：
¥2200.00
美元价：
1320.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Motilide;Idremcinal;8,9-Didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin |
| ProductType | Chemical |
| Properties | |
| Formula | C39H69NO12 |
| MW | 744.0 |
| CAS | 110480-13-2 |
| Source/HostChemicals | SemisyntheticfromerythromycinA. |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Whitetooff-whitepowder. |
| Solubility | Solubleinmethanol,ethanol,DMSO,chloroform,acetone,ethylacetateoracetonitrile.Insolubleinwaterorhexane. |
| Declaration | SynthesizedbytheOrganicChemistryGroupofTheKitasatoInstitute. |
| InChiKey | FPBKIOZMKHHNLL-FMUXYZBNSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. |
| Use/StABIlity | Stableforatleast3yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Showsstronggastrointestinalmotorstimulating(GMS)activity[1,2,5].
- MotilinreceptoragoNIST[3,6].
- Stimulatessmoothmusclecellcontraction[3].
- Stimulatescholinergicneuronsinanon-vagalpathway[4].
- Enhancesgastrointestinalcontractileactivityandacceleratesgastricemptying[7,8].
- Showsorexigenicactivitywithaffinityforthegrowth-hormonesecretagoguereceptor(GHS-R,ghrelinreceptor)[9].
ProductReferences
- Gastrointestinalmotor-stimulatingactivityofmacrolideantibioticsandthestructure-activityrelationship:S.Omura,etal.;J.Antibiot.(Tokyo)38,1631(1985)
- Macrolideswithgastrointestinalmotorstimulatingactivity:S.Omura,etal.;J.Med.Chem.30,1941(1987)
- EM574,anerythromycinderivative,isapotentmotilinreceptoragonistinhumangastricantrum:M.Satoh,etal.;J.Pharmacol.Exp.Ther.271,574(1994)
- Vagus-dependentandvagus-independentmechanismsofactionoftheerythromycinderivativeEM574andmotilinindogs:N.Inatomi,etal.;Jpn.J.Pharmacol.71,29(1996)
- BioactivemetabolitesofEM574andEM523,erythromycinderivativeshavingstronggastrointestinalmotorstimulatingactivity:Y.Funabashi,etal.;J.Antibiot.(Tokyo)49,794(1996)
- EM574,anerythromycinderivative,isamotilinreceptoragonistintherabbit:F.Sato,etal.;Eur.J.Pharmacol.322,63(1997)
- EffectsofEM574andcisaprideongastriccontractileandemptyingactivityinnormalanddrug-inducedgastroparesisindogs:T.Tanaka,etal.;J.Pharmacol.Exp.Ther.287,712(1998)
- EffectofEM574onpostprandialpancreaticobiliarysecretion,gastricmotoractivity,andemptyinginconsciousdogs:T.Tanaka,etal.;Dig.Dis.Sci.44,1100(1999)
- EM574,amotilide,hasanorexigenicactivitywithaffinityforgrowth-hormonesecretagoguereceptor:A.Asakawa,etal.;J.Gastroenterol.Hepatol.18,881(2003)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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