Adipogen/Echinomycin/BVT-0267-M001/1 mg
商品编号：
BVT-0267-M001
品牌：
Adipogen Inc
市场价：
¥1700.00
美元价：
1020.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Quinomycin A |
| Product Type | Chemical |
| Properties | |
| Formula | C51H64N12O12S2 |
| MW | 1101.3 |
| Merck Index | 14: 3497 |
| CAS | 512-64-1 |
| RTECS | JW5250000 |
| Source/Host Chemicals | Isolated from Streptomyces echinatus (DSM 40013). |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in acetone, DMSO, methanol, dichloromethane or ethyl acetate. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| Other Product Data | Contains traces of water. |
| InChi Key | AUJXLBOHYWTPFV-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Hygroscopic. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Antibiotic.
- Antitumor compound.
- Powerful, selective inhibitor of nucleic acid synthesis in vitro.
- Potent hypoxia-inducible factor 1 (HIF-1) DNA binding activity inhibitor.
- Apoptosis inducer.
- Antibacterial, antifungal and antiviral.
Product References
- A "quinoxaline antibiotic" similar to the triostins, q.v.: I. Kuroya, et al.; J. Antibiot. 14A, 324 (1961)
- Identity of levomycin and quinomycin A (echimomycin): K. Katagiri, et al.; J. Antibiot. 15, 273 (1962)
- The mode of action of quinoxaline antibiotics. Interaction of quinomycin A with deoxyribonucleic acid: K. Sato, et al.; J. Antibiot. 20, 270 (1967)
- Echinomycin binding sites on DNA: M.M. Van Dyke & P.B. Dervan; Science 225, 1122 (1984)
- Sequence-specific binding of echinomycin to DNA: evidence for conformational changes affecting flanking sequences: C.M. Low, et al.; Nucl. Acids Res. 12, 4865 (1984)
- Kinetic evidence that echinomycin migrates between potential DNA binding sites: K.R. Fox & M.J. Waring; Nucl. Acids Res. 13, 595 (1985)
- Effect of echinomycin on DNA methylation: R.L. Adams & A. Rinaldi; FEBS Lett. 215, 266 (1987)
- Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway: J.Y. Park, et al.; Pharmacol. Res. 50, 201 (2004)
- Echinomycin inhibits chromosomal DNA replication and embryonic development in vertebrates: L.G. May et al.; Nucl. Acids Res. 32, 65 (2004)
- Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity: D. Kong, et al.; Cancer Res. 65, 9047 (2005)
- Molecular signaling cascade in DNA bisintercalator, echinomycin-induced apoptosis of HT-29 cells: evidence of the apoptotic process via activation of the cytochrome c-ERK-caspase-3 pathway: J.Y. Park, et al.; Int. J. Biochem. Cell Biol. 38, 244 (2006)
- Synergistic effects of CoCl(2) and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells: E. Pacary, et al.; J. Cell Sci. 119, 2667 (2006)
- Interaction of an echinomycin-DNA complex with manganese ions: R. Pfoh, et al.; Acta Cryst. F65, 660 (2009)
- Recent developments in bisintercalator natural products: O.E. Zolova, et al.; Biopolymers 93, 777 (2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
