Adipogen/Ebselen/AG-CR1-0031-M025/25 mg
商品编号：
AG-CR1-0031-M025
品牌：
Adipogen Inc
市场价：
¥1200.00
美元价：
720.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2-Phenyl-1,2-benzisoselenazol-3-(2H)-one |
| ProductType | Chemical |
| Properties | |
| Formula | C13H9NOSe |
| MW | 274.2 |
| MerckIndex | 14:3486 |
| CAS | 60940-34-3 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSOor100%ethanol. |
| Identity | Determinedby1H-NMR. |
| InChiKey | DYEFUKCXAQOFHX-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Glutathioneperoxidasemimetic[1,4].
- Peroxynitritescavenger[4].
- Anti-inflammatory[1,5-7]
- Antioxidant[2,3,5].
- ProteinkinaseC(PKC),NADPH,lipoxygenase,COX,NOS,H+-ATPaseandNADPHoxidaseinhibitor[6-9].
- Antifungal[9].
- Review[10].
- PotentIDO-1inhibitorwithKi94nM[11].
- InhibitorofHIV-1capsidC-terminaldomaindimerization.
ProductReferences
- AnovelBIOLOGicallyactiveseleno-organiccompound--III.EffectsofPZ51(Ebselen)onglutathioneperoxidaseandsecretoryactivitiesofmousemacrophages:M.J.Parnham&S.Kindt;Biochem.Pharmacol. 33,3247(1984)
- Seleno-organiccompoundsandthetherapyofhydroperoxide-linkedpathologicalconditions:M.J.Parnham&E.Graf;Biochem.Pharmacol. 36,3095(1987)
- Kineticmechanismandsubstratespecificityofglutathioneperoxidaseactivityofebselen(PZ51):M.Maiorino,etal.;Biochem.Pharmacol. 37,2267(1988)
- Ebselenasaglutathioneperoxidasemimicandasascavengerofperoxynitrite:H.Sies&H.Masumoto;Adv.Pharmacol.38,229(1997)
- Ebselen,aglutathioneperoxidasemimeticseleno-organiccompound,asamultifunctionalantioxidant.Implicationforinflammation-associatedcarcinogenesis:Y.Nakamura,etal.;J.Biol.Chem.277,2687(2002)
- Molecularactionsofebselen-anantiinflammatoryantioxidant:T.Schewe;Gen.Pharmacol. 26,1153(1995)
- Studiesontheanti-inflammatoryactivityofebselen.EbseleninterfereswithgranulocyteoxidativeburstbydualinhibitionofNADPHoxidaseandproteinkinaseC?:I.A.Cotgreave,etal.;Biochem.Pharmacol. 38,649(1989)
- Stronginhibitionofmammalianlipoxygenasesbytheantiinflammatoryseleno-organiccompoundebselenintheabsenceofglutathione:C.Schewe,etal.;Biochem.Pharmacol. 48,65(1994)
- EvaluationoftheantifungalandplasmamembraneH+-ATPaseinhibitoryactionofebselenandtwoebselenanalogsinS.cerevisiaecultures:B.Billack,etal.;J.EnzymeInhib.Med.Chem.25,312(2010)
- Ebselen:athioredoxinreductase-dependentcatalystforalpha-tocopherolquinonereduction:J.Fang,etal.;Toxicol.Appl.Pharmacol.207,103(2005)
- Theselenazaldrugebselenpotentlyinhibitsindoleamine2,3-dioxygenasebytargetingenzymecysteineresidues:A.C.Terentis,etal.Biochem.49,591(2010)
- Ebselen,asmall-moleculecapsidinhibitorofHIV-1replication:S.Thenin-Houssier,etal.;Antimicrob.AgentsChemother.60,2195(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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