Adipogen/DYRK1A/B Inhibitor AnnH31/AG-CR1-3650-C500/500 µg
商品编号：
AG-CR1-3650-C500
品牌：
Adipogen Inc
市场价：
¥2600.00
美元价：
1560.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2-(7-Methoxy-1-methyl-9H-pyrido[3,4-b]indol-9-yl)acetonitrile;AnnH31 |
| ProductType | Chemical |
| Properties | |
| Formula | C15H13N3O |
| MW | 251.3 |
| CAS | 241809-12-1 |
| PurityChemicals | ≥98%(HPLC,NMR) |
| Appearance | Off-whitetotansolid. |
| Solubility | SolubleinDMSO. |
| Identity | Determinedby1H-NMR. |
| OtherProductData | DMSOStockSolution:PriortoperformingBIOLOGicalexperimentstheDMSOstocksolutionshouldbefurtherdilutedintowaterorotheraqueousbufferstoensurethattheresidualamountofDMSOisinsignificant,sinceDMSOmayhavephysiologicaleffectsathighconcentrations. |
| InChiKey | FCFDJQKAPLIDTQ-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentselectivemembrane-permeableDYRK1A(IC50=81nM)andDYRK1Binhibitor.Off-targetinhibitionofCLK1andslightlyDYRK2andHIPK2.
- ShowsminimalinhibitoryeffectsonmonoamineoxidaseA(MAOA)(IC50=3.2µg),with40-foldselectivityforDYRK1AoverMAOA.
- Dose-dependentlyreducedthephosphorylationofthreeknownDYRK1Asubstrates(SF3B1,SEPT4andtau)withoutnegativeeffectsoncellviabilityincelularassays.
- ShowscytotoxiceffectsinHeLacellsathighconcentrations(3-10µM).
- ThepleiotropicproteinkinaseDYRK1Ahasdiversefunctionsincellcyclecontrol,neuronaldifferentiationandsynaptictransmissionandhasattractedincreasinginterestasapotentialdrugtarget,duetoitsroleinthepathologyofDownsyndrome,neurodegenerativediseasessuchasAlzheimer"sdiseaseandcancer.ThecloselyrelatedkinaseDYRK1BhasbeenassociatedwithcancercellsurvivalbyarrestingcellsinaquiescentstatetoallowcellularrepairandmutationsinDYRK1Bmightbecausativeinmetabolicsyndrome.
ProductReferences
- Selectivityprofilingandbiologicalactivityofnovelbeta-carbolinesaspotentandselectiveDYRK1kinaseinhibitors:K.Ruben,etal.;PLosOne10,e0132453(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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