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Adipogen/Ds(+)-threo-Isocitric acid . trisodium salt/AG-CR1-3505-M025/25 mg
Adipogen/Ds(+)-threo-Isocitric acid . trisodium salt/AG-CR1-3505-M025/25 mg
商品编号：
AG-CR1-3505-M025
品牌：
Adipogen Inc
市场价：
¥1000.00
美元价：
600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylicacid;(2R,3S)-Isocitricacid.trisodiumsalt |
| ProductType | Chemical |
| Properties | |
| Formula | C6H5O7.3Na |
| MW | 189.1.69.0 |
| CAS | 903507-52-8 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Whitesolid. |
| Solubility | Solubleinwater. |
| Identity | Determinedby1H-NMR.Iron-free. |
| InChiKey | HWMVXEKEEAIYGB-UHFFFAOYSA-K |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Anticoagulantthatretainsplateletsfunctionality.
- BuffersCa2+activityinphysiologicalrange(~1mM).
- Bypassesthemetabolicblockade,maypermithemebiosynthesisbutdoesnotsufficetoreversetheiron-restrictionresponse.
- Stabilizestheiron-sulfurclusterandispredictedtorestoreaconitasetoits"highiron"conformationandtherebydissociatesthePKC-associatedsignalingcomplexeswhosehyperactivationimpairsEporesponsiveness.
- BindsIDH(isocitratedehydrogenase),anexcellentcandidateforparticipating,alongwithaconitaseandPKC,inanironrestrictionsignalosome.
- Contributestohemebiosynthesiswhichmayaccountforitsgreaterpotencyinrestoringerythroiddifferentiation.
ProductReferences
- IsocitrateasCalciumIonActivityBufferinCoagulationAssays:M.Ranby,etal.;Clin.Chem.45,1176(1999)
- SyntheseswithaChiralBuildingBlockfromtheCitricAcidCycle:(2R,3S)-IsocitricAcidbyFermentationofSunflowerOil:P.Heretsch,etal.;Angew.Chem.Int.Ed.47,1958(2008)
- Cancer-associatedIDH1mutationsproduce2-hydroxyglutarate:L.Dang,etal.;Nature462,739(2009)
- Ironcontroloferythroiddevelopmentbyanovelaconitase-associatedregulatorypathway:G.C.Bullock,etal.;Blood116,97(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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