Adipogen/DMNQ/AG-CR1-3598-M025/25 mg
商品编号：
AG-CR1-3598-M025
品牌：
Adipogen Inc
市场价：
¥4600.00
美元价：
2760.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2,3-Dimethoxy-1,4-naphthoquinone;2,3-diOMe-1,4-NQ |
| ProductType | Chemical |
| Properties | |
| Formula | C12H10O4 |
| MW | 218.2 |
| CAS | 6956-96-3 |
| PurityChemicals | ≥99%(NMR) |
| Appearance | Yellowcrystallinesolid. |
| Solubility | SolubleinDMSOormethanol. |
| Identity | Determinedby1H-NMR. |
| InChiKey | ZEGDFCCYTFPECB-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeable,non-alkylating,non-thiol,adduct-forming,redoxcyclingquinone.
- Intracellularsuperoxideanionformation/ROSgenerationinducer.
- Anticanceragent.Showntoinducecellproliferation,apoptosis,necrosisandnecroptosisinvitro,dependentonconcentration,time,temperatureandcelltype.
- Valuabletoolforthegenerationofreactiveoxygenspecies(ROS)inordertostudytheroleofROSincelltoxicity,apoptosisandnecrosis.
- Usefulasreferencecompoundincharacterizingtheeffectsofoxidativestress.CanbeusedtoeliminateanymechaNISTicambiguityinvolvingredoxcyclingquinoidsasthesourceofreactiveoxidantspecies/oxidativestressinBIOLOGicalstudies.
ProductReferences
- Theroleofoxidativeprocessesinthecytotoxicityofsubstituted1,4-naphthoquinonesinisolatedhepatocytes:D.Ross,etal.;Arch.Biochem.Biophys.248,460(1986)
- Redoxcyclingandsulphydrylarylation;theirrelativeimportanceinthemechanismofquinonecytotoxicitytoisolatedhepatocytes:T.W.Gant,etal.;Chem.Biol.Interact.65,157(1988)
- Quinone-inducedDNAsinglestrandbreaksinrathepatocytesandhumanchronicmyelogenousleukaemicK562cells:W.A.Morgan,etal.;Biochem.Pharmacol.44,215(1992)
- Quinone-inducedoxidativestresselevatesglutathioneandinducesgamma-glutamylcysteinesynthetaseactivityinratlungepithelialL2cells:M.M.Shi,etal.;J.Biol.Chem.269,26512(1994)
- Differentprooxidantlevelsstimulategrowth,triggerapoptosis,orproducenecrosisofinsulin-secretingRINm5Fcells:J.M.Dypbukt,etal.;J.Biol.Chem.269,30553(1994)
- DNAsingle-strandbreakageinmammaliancellsinducedbyredoxcyclingquinonesintheabsenceofoxidativestress:W.A.Morgan;J.Biochem.Toxicol.10,227(1995)
- Naphthoquinone-inducedDNAdamageintheabsenceofoxidativestress:W.A.Morgan;Biochem.Soc.Trans.23,225S(1995)
- Differentialmechanismsofcellkillingbyredoxcyclingandarylatingquinones:T.R.Henry&K.B.Wallace;Arch.Toxicol.70,482(1996)
- Naphthazarinderivatives:synthesis,cytotoxicmechanismandevaluationofantitumoractivity:Y.J.You,etal.;Arch.Pharm.Res.21,595(1998)
- Temperature-dependentquinonecytotoxicityinplateletsinvolvesarylation:Y.A.Kang,etal.;J.Toxicol.Environ.HealthA65,1367(2002)
- Superoxidetargetscalcineurinsignalinginvascularendothelium:D.Namgaladze,etal.;BBRC334,1061(2005)
- OxidativestresspromotespolarizationofhumanTcelldifferentiationtowardaThelper2phenotype:M.R.King,etal.;J.Immunol.176,2765(2006)
- Caspase-2activationinneuralstemcellsundergoingoxidativestress-inducedapoptosis:C.Tamm,etal.;Apoptosis13,354(2008)
- AReceptor-interactingProtein1(Rip1)IndependentNecroticDeathUnderTheControlOfProteinPhosphatasePp2aThatInvolvesTheReorganizationOfActinCytoskeletonAndTheActionOfCofilin-1:A.Tomasella,etal.;J.Biol.Chem.289,25699(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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