Adipogen/DMAT/AG-CR1-3654-M005/5 mg
商品编号：
AG-CR1-3654-M005
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole;4,5,6,7-Tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine |
| ProductType | Chemical |
| Properties | |
| Formula | C9H7Br4N3 |
| MW | 476.8 |
| CAS | 749234-11-5 |
| PurityChemicals | ≥96%(HPLC) |
| Appearance | Solid. |
| Solubility | SolubleinDMSO(10mg/ml). |
| Identity | Determinedby1H-NMR. |
| InChiKey | SLPJGDQJLTYWCI-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotenthighaffinityATP-competitiveinhibitorofcaseinkinaseII(CK2)(IC50=0.13µM).InhibitsCK2inratliverwith>1000-foldgreaterselectivityforCK2thanforCK1(IC50=140nMand>200μM,respectively).
- DYRK1AandDYRK2inhibitor(IC50=~0.4µMforboth).
- Showntoinhibitadditionalkinases,suchasPIM1,PIM3,HIPK2,HIPK3,PKD1andCDK2inthesubmicromolarrange.
- Anticanceragent.Apoptosisinducerindifferentcancercelllines.
- Inducesreactiveoxygenspecies(ROS)andDNAdoublestrandbreaksintumorcells.
- Inducesapoptosisincellsexpressinganinhibitor-resistantCK2,byinhibitingquinonereductase2(NQO2),bindingwithsimilaraffinitiestotheoxidizedandreducedformsofNQO2.
- Usefulforinvivostudiesduetocellpermeabilityandhighefficacyinculturedcellsandimplicationsinresearchandtreatmentofneoplasiaandinfectivediseases,inwhichCK2playsarole.
ProductReferences
- OptimizationofproteinkinaseCK2inhibitorsderivedfrom4,5,6,7-tetrabromobenzimidazole:M.A.Pagano,etal.;J.Med.Chem.47,6239(2004)
- 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole:anovelpowerfulandselectiveinhibitorofproteinkinaseCK2:M.A.Pagano,etal.;BBRC321,1040(2004)
- InductionofcelldeathinantiestrogenresistanthumanbreastcancercellsbytheproteinkinaseCK2inhibitorDMAT:C.W.Yde,etal.;CancerLett.256,229(2007)
- TheselectivityofinhibitorsofproteinkinaseCK2:anupdate:M.A.Pagano,etal.;Biochem.J.415,353(2008)
- DMAT,aninhibitorofproteinkinaseCK2inducesreactiveoxygenspeciesandDNAdoublestrandbreaks:C.C.Schneider,etal.;Oncol.Rep.21,1593(2009)
- Anti-neoplasticeffectofproteinkinaseCK2inhibitor,2-dimethylamino-4,5,6,7-tetrabromobenzimidazole(DMAT),ongrowthandhormonalactivityofhumanadrenocorticalcarcinomacellline(H295R)invitro:H.Lawnicka,etal.;CellTissueRes.340,371(2010)
- InhibitionofexperimentalHCCgrowthinmicebyuseofthekinaseinhibitorDMAT:G.Sass,etal.;Int.J.Oncol.39,433(2011)
- Quinonereductase2isanadventitioustargetofproteinkinaseCK2inhibitorsTBBz(TBI)andDMAT:K.K.Leung&B.H.Shilton;Biochemistry54,47(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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