Adipogen/DMAPB/AG-CR1-3904-M001/1 mg
商品编号：
AG-CR1-3904-M001
品牌：
Adipogen Inc
市场价：
¥3000.00
美元价：
1800.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 4-(Dimethylamino)-N-(5-(2-mercaptoacetamido)pentyl)benzamide;MercaptoacetamideBC-4-55 |
| ProductType | Chemical |
| Properties | |
| Formula | C16H25N3O2S |
| MW | 323.5 |
| CAS | 827036-76-0 |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Off-whitesolid. |
| Solubility | SolubleinDMSO,ethanolormethanol. |
| Identity | Determinedby1H-NMR. |
| InChiKey | SGOHSANPZHQNKM-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeable,potentandselectiveclassIIbHDAC6inhibitor(IC50=114nM).DisplaysselectivityoverotherHDACs(IC50=1-8µM).
- Neuroprotectiveandanti-neuroinflammatoryagent.Reducedneuronaldegenerationaftertraumaticbraininjury(TBI).
- ShowntoincreasehistoneH3acetylation.
- HDAC6deacetylatestubulin,HSP90andthecorehistones(H2A,H2B,H3,H4).Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.HDAC6playsanimportantroleinmicrotubule-dependentcellmotility,transcriptionalregulation,degradationofmisfoldedproteinsandcellcycleandisinvolvedinautophagy,inflammation,cancerandneurodegeneration.
ProductReferences
- ChemistryandBIOLOGyofmercaptoacetamidesasnovelhistonedeacetylaseinhibitors:B.Chen,etal.;Bioorg.Med.Chem.Lett.15,1389(2005)
- Functionaldifferencesinepigeneticmodulators-Superiorityofmercaptoacetamide-basedhistonedeacetylaseinhibitorsrelativetohydroxamatesincorticalneuronneuroprotectionstudies:A.Kozikowski,etal.;J.Med.Chem.50,3054(2007)
- Invitroplasmastability,permeabilityandsolubilityofmercaptoacetamidehistonedeacetylaseinhibitors:R.Konsoula&M.Jung;Int.J.Pharm.361,19(2008)
- HDACinhibitorincreaseshistoneH3acetylationandreducesmicrogliainflammatoryresponsefollowingtraumaticbraininjuryinrats:B.Zhang,etal.;BrainRes.1226,181(2008)
- Novelinhibitorsofhumanhistonedeacetylase(HDAC)identifiedbyQSARmodelingofknowninhibitors,virtualscreening,andexperimentalvalidation:H.Tang,etal.;J.Chem.Inf.Model49,461(2009)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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