Adipogen/Digoxin/CDX-D0175-G001/1 g
商品编号：
CDX-D0175-G001
品牌：
Adipogen Inc
市场价：
¥2120.00
美元价：
1272.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 12β-Hydroxydigitoxin;NSC95100 |
| ProductType | Chemical |
| Properties | |
| Formula | C41H64O14 |
| MW | 780.94 |
| CAS | 20830-75-5 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Whitepowder. |
| Solubility | SolubleinDMSO(100mM)ormethanol. |
| Identity | DeterminedbyNMR. |
| Declaration | ManufacturedbyChemodex. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | LTMHDMANZUZIPE-PUGKRICDSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
CardiacglycosidefromtheleavesofDigitalislanata.Itisusedtotreatcardiacarrhythmias.ItisoftenusedasamodelsubstrateofP-glycoprotein(Pgp)(0.01-10µM)andaninhibitorofNa+/K+-ATPase.Inhibitsmembrane-boundα-subunitsoftheNa+/K+ATPasepumpinmyocytes.TheprimarymechanismofactioninvolvesinhibitionoftheNa+/K+ATPase,mainlyinthemyocardium.Thisinhibitioncausesanincreaseinintracellularsodiumlevels,resultinginareversaloftheactionofthesodium-calciumexchanger,whichcausesanincreaseintheintracellularcalciumconcentration.Thisleadstoadecreaseinheartrateandincreasedstorageofcalciuminthesarcoplasmicreticulum,causingacorrespondingincreaseinthereleaseofcalciumduringeachactionpotential.
ProductReferences
(1)R.G.Woolfson,etal.;KidneyInt.46,297(1994)|(2)S.Reddy,etal.;Curr.Opin.Cardiol.12,233(1997)|(3)K.Kjeldsen&H.Bundgaard;Ann.NYAcad.Sci.986,702(2003)|(4)M.Gheorghiade,etal.;Circulation109,2959(2004)|(5)M.Ehle,etal.;Crit.Pathw.Cardiol.10,93(2011)|(6)R.J.Biggar;Clin.CancerRes.18,2133(2012)|(7)A.M.Nader&D.R.Foster;J.Clin.Pharmacol.54,3(2014)|(8)G.A.Ewy;Am.J.Med.128,1272(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
